YNT 185

Name: YNT 185
Brand: Tocris Bioscience
SKU: 6739

Tocris Bioscience, part of Bio-Techne | Catalog # 6739

Citations (2)

COA / SDS

Potent and selective OX2 agonist

Key Product Details

Description:	Potent and selective OX₂ agonist
Chemical Name:	3'-[[[3-[[2-[[2-(Dimethylamino)benzoyl]amino]ethyl]amino]phenyl]amino]sulfonyl]-4'-methoxy-N,N-dimethyl-[1,1'-biphenyl]-3-carboxamide dihydrochloride
Purity:	≥98% (HPLC)
Molecular Weight:	688.66

View Full Technical Details for YNT 185

Technical Data
Citations

Biological Activity for YNT 185

YNT 185 is a potent and selective orexin OX₂ receptor agonist (EC₅₀ = 28 nM at human OX₂ expressed in CHO cells). Displays approximately 100-fold selectivity for OX₂ over OX₁ (EC₅₀ = 2.75 μM at human OX₁ expressed in CHO cells). Depolarizes OX₂-expressing histaminergic neurons in mouse brain slices. Increases wake time in wild type mice. Suppresses cataplexy-like symptoms in OX knockout mice.

Compound Libraries for YNT 185

YNT 185 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for YNT 185

M. Wt	688.66
Formula	C₃₃H₃₇N₅O₅S.2HCl
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	1804978-82-2
PubChem ID	140307520
InChi Key	AIORBDHFHVKRIY-UHFFFAOYSA-N
Smiles	COC1=C(S(=O)(NC2=CC(NCCNC(C3=C(N(C)C)C=CC=C3)=O)=CC=C2)=O)C=C(C4=CC(C(N(C)C)=O)=CC=C4)C=C1.Cl.Cl

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for YNT 185

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	68.87	100
	DMSO	68.87	100

Preparing Stock Solutions for YNT 185

The following data is based on the product molecular weight 688.66.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.45 mL	7.26 mL	14.52 mL
5 mM	0.29 mL	1.45 mL	2.90 mL
10 mM	0.15 mL	0.73 mL	1.45 mL
50 mM	0.03 mL	0.15 mL	0.29 mL

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References for YNT 185

References are publications that support the biological activity of the product.

Irukayama-Tomobe Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models. Proc.Natl.Acad.Sci.USA. 2017 PMID: 28507129
Nagahara Design and synthesis of non-peptide, selective orexin receptor 2 agonists. J.Med.Chem. 2015 PMID: 26267383