Yoda 2

Name: Yoda 2
Brand: Tocris Bioscience
SKU: 8051

Tocris Bioscience, part of Bio-Techne | Catalog # 8051

COA / SDS

Piezo1 channel activator

Key Product Details

Description:	Piezo1 channel activator
Chemical Name:	Potassium 4-(5-((2,6-dichlorobenzyl)thio)-1,3,4-thiadiazol-2-yl)benzoate
Purity:	≥97% (HPLC)
Molecular Weight:	435.38

View Full Technical Details for Yoda 2

Technical Data
Citations

Biological Activity for Yoda 2

Yoda 2 is a selective Piezo1 channel activator (EC₅₀ values are 150 nM and 1.14 μM in mPiezo1 and HUVEC cells respectively). Increases Ca²⁺ signaling 2.8 fold in hPIEZO-TREx and 1.2 fold in mPIEZO1-TREx, compared to Yoda 1 (Cat. No. 5586). Induces concentration-dependent relaxation of mouse portal vein (EC₅₀ = 1.2 μM). Suitable for use in vivo and in vitro.

Technical Data for Yoda 2

M. Wt	435.38
Formula	C₁₆H₉Cl₂N₂O₂S₂K
Storage	Store at -20°C
Purity	≥97% (HPLC)
InChi Key	OQEIWUHZUPFUQU-UHFFFAOYSA-M
Smiles	O=C([O-])C1=CC=C(C2=NN=C(SCC3=C(Cl)C=CC=C3Cl)S2)C=C1.[K+]

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Yoda 2

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	43.54	100
	DMSO	21.77	50

Preparing Stock Solutions for Yoda 2

The following data is based on the product molecular weight 435.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.30 mL	11.48 mL	22.97 mL
5 mM	0.46 mL	2.30 mL	4.59 mL
10 mM	0.23 mL	1.15 mL	2.30 mL
50 mM	0.05 mL	0.23 mL	0.46 mL

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References for Yoda 2

References are publications that support the biological activity of the product.

Parsonage Improved PIEZO1 agonism through 4-benzoic acid modification of Yoda1. Br.J.Pharmacology 2023 PMID: 36457143