Z-DEVD-FMK

Name: Z-DEVD-FMK
Brand: Tocris Bioscience
SKU: 2166

Tocris Bioscience, part of Bio-Techne | Catalog # 2166

COA / SDS

New Version Available - 8009

Cell-permeable, irreversible caspase-3 inhibitor

Discontinued Product

2166 has been discontinued. An alternative/replacement product is available: 8009. View all Caspase Inhibitors products.

Key Product Details

Description:	Cell-permeable, irreversible caspase-3 inhibitor
Chemical Name:	Benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethylketone
Molecular Weight:	668.67

View Full Technical Details for Z-DEVD-FMK

Technical Data
Citations

Biological Activity for Z-DEVD-FMK

Z-DEVD-FMK is a cell-permeable, irreversible inhibitor of caspase-3/CPP32; inhibits tumor cell apoptosis. Neuroprotective in rat hippocampus following seizures in vivo.

Technical Data for Z-DEVD-FMK

M. Wt	668.67
Formula	C₃₀H₄₁FN₄O₁₂
Single Letter Sequence	DEVD (Modifications: Asp-1 = Z-Asp(OMe), Glu-2 = Glu(OMe), Asp-4 = (OMe)-fluoromethylketone)
Storage	Store at -20°C
CAS Number	210344-95-9
PubChem ID	16760394
InChi Key	GBJVAVGBSGRRKN-JYEBCORGSA-N
Smiles	[H]N([C@@H](CC(=O)OC)C(=O)N[C@@H](CCC(=O)OC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(=O)OC)C(=O)CF)C(=O)OCC1=CC=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

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References for Z-DEVD-FMK

References are publications that support the biological activity of the product.

Henshall Involvement of caspase-3-like protease in the mechanism of cell death following focally evoked limbic seizures. J.Neurochem. 2000 PMID: 10693954
Kugawa Apoptosis of NG108-15 cells induced by Bupren. hydrochloride occurs via the caspase-3 pathway. Biol.Pharm.Bull. 2000 PMID: 10963298
Brocksted Identification of apoptosis-associated proteins in a human Burkitt lymphoma cell line. J.Biol.Chem. 1998 PMID: 9774422

Z-DEVD-FMK

Tocris Bioscience, part of Bio-Techne | Catalog # 2166

Key Product Details

Biological Activity for Z-DEVD-FMK

Technical Data for Z-DEVD-FMK

Molarity Calculator

Dilution Calculator

Reconstitution Calculator

References for Z-DEVD-FMK

Product Documents for Z-DEVD-FMK

COA

Certificate of Analysis

SDS

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