Zileuton

Name: Zileuton
Brand: Tocris Bioscience
SKU: 3308

Tocris Bioscience, part of Bio-Techne | Catalog # 3308

Citations (20)

COA / SDS

5-LOX inhibitor; orally bioavailable

Key Product Details

Description:	5-LOX inhibitor; orally bioavailable
Alternative Names:	ICI D2138
Chemical Name:	N-(1-Benzo[b]thien-2-ylethyl)-N-hydroxyurea
Purity:	≥99% (HPLC)
Molecular Weight:	236.29

View Full Technical Details for Zileuton

Technical Data
Citations

Biological Activity for Zileuton

Zileuton is an orally active 5-lipoxygenase (5-LOX) inhibitor that inhibits LTB₄ synthesis (IC₅₀ values are 0.56, 2.3 and 2.6 μM in dog, rat and human blood respectively). Inhibits antigen-induced contraction of tracheal strips in vitro (IC₅₀ = 6 μM) and exhibits antiasthmatic activity in vivo. Also weakly inhibits CYP1A2 (K_i = 66 - 98 μM). Ferroptosis inhibitor.

Compound Libraries for Zileuton

Zileuton is also offered as part of the Tocriscreen 2.0 Max and Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.

Technical Data for Zileuton

M. Wt	236.29
Formula	C₁₁H₁₂N₂O₂S
Storage	Store at +4°C
Purity	≥99% (HPLC)
CAS Number	111406-87-2
PubChem ID	60490
InChi Key	MWLSOWXNZPKENC-UHFFFAOYSA-N
Smiles	CC(N(O)C(N)=O)C2=CC1=CC=CC=C1S2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Zileuton

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	23.63	100

Preparing Stock Solutions for Zileuton

The following data is based on the product molecular weight 236.29.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	4.23 mL	21.16 mL	42.32 mL
5 mM	0.85 mL	4.23 mL	8.46 mL
10 mM	0.42 mL	2.12 mL	4.23 mL
50 mM	0.08 mL	0.42 mL	0.85 mL

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References for Zileuton

References are publications that support the biological activity of the product.

Xie Ferroptosis: process and function. Cell Death Differ. 2016 PMID: 26794443
Malo The 5-lipoxygenase inhibitory activity of zil. in in vitro and in vivo models of antigen-induced airway anaphylaxis. Pulm.Pharmacol. 1994 PMID: 8081074
Lu Mechanism-based inhibition of human liver microsomal cytochrome P450 1A2 by zileuton, a 5-lipoxygenase inhibitor. Drug Metab.Dispos. 2003 PMID: 14570767
McMillan Pre-clinical pharmacology of ICI D2138, a potent orally-active non-redox inhibitor of 5-lipoxygenase. Br.J.Pharmacol. 1992 PMID: 1334748

Product Documents for Zileuton

COA

Certificate of Analysis

To download a Certificate of Analysis, please select a batch below.

SDS

⚠ WARNING: This product can expose you to chemicals including Zileuton, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov