ZJ 43

Name: ZJ 43
Brand: Tocris Bioscience
SKU: 2675

Tocris Bioscience, part of Bio-Techne | Catalog # 2675

Citations (10)

COA / SDS

Glutamate carboxypeptidase II and III (NAALADase, NAAG peptidase) inhibitor

Key Product Details

Description:	Glutamate carboxypeptidase II and III (NAALADase, NAAG peptidase) inhibitor
Chemical Name:	N-[[[(1S)-1-Carboxy-3-methylbutyl]amino]carbonyl]-L-glutamic acid
Purity:	≥95% (HPLC)
Molecular Weight:	304.3

View Full Technical Details for ZJ 43

Technical Data
Citations

Biological Activity for ZJ 43

ZJ 43 is a potent inhibitor of glutamate carboxypeptidase II and III (GCP II and III/NAAG peptidase/NAALADase) (K_i values are 0.8 and 23 nM respectively) that inhibits the hydrolysis of NAAG (IC₅₀ = 2.4 nM). Does not directly interact with NMDA or metabotropic glutamate receptors. Reduces neuronal degeneration in a rat model of traumatic brain injury (TBI) and reduces locomotor activity in the PCP-model of schizophrenia.

Licensing Information

Sold with the permission of Acenta Discovery, Inc.

Technical Data for ZJ 43

M. Wt	304.3
Formula	C₁₂H₂₀N₂O₇
Storage	Store at -20°C
Purity	≥95% (HPLC)
CAS Number	723331-20-2
PubChem ID	11722553
InChi Key	BSGWCSGMXAVYRT-YUMQZZPRSA-N
Smiles	CC(C[C@@]([H])(C(O)=O)NC(N[C@@]([H])(CCC(O)=O)C(O)=O)=O)C

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for ZJ 43

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	30.43	100
	DMSO	30.43	100

Preparing Stock Solutions for ZJ 43

The following data is based on the product molecular weight 304.3.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.29 mL	16.43 mL	32.86 mL
5 mM	0.66 mL	3.29 mL	6.57 mL
10 mM	0.33 mL	1.64 mL	3.29 mL
50 mM	0.07 mL	0.33 mL	0.66 mL

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References for ZJ 43

References are publications that support the biological activity of the product.

Zhou NAAG peptidase inhibitors and their potential for diagnosis and therapy. Nat.Rev.Drug Discov. 2005 PMID: 16341066
Yamamoto Local administration of N-acetylaspartylglutamate (NAAG) peptidase inhibitors is analgesic in peripheral pain in rats. Eur.J.Neurosci. 2007 PMID: 17241276
Olszewski NAAG peptidase inhibition reduces locomotor activity and some stereotypes in the PCP model of schizophrenia via group II mGluR. J.Neurochem. 2004 PMID: 15140187