ZM 449829

Name: ZM 449829
Brand: Tocris Bioscience
SKU: 1366

Tocris Bioscience, part of Bio-Techne | Catalog # 1366

COA / SDS

Potent, selective JAK3 inhibitor

Discontinued Product

1366 has been discontinued. View all JAK Kinase Inhibitors products.

Key Product Details

Description:	Potent, selective JAK3 inhibitor
Chemical Name:	1-(2-Naphthalenyl)-2-propen-1-one
Purity:	≥98% (HPLC)
Molecular Weight:	182.22

View Full Technical Details for ZM 449829

Technical Data
Citations

Biological Activity for ZM 449829

ZM 449829 is a potent, selective inhibitor of Janus tyrosine kinase 3 (JAK3) which binds competitively to the JAK3 ATP site. pIC₅₀ values are 6.8, 5.0, 4.7, and < 5.0 for JAK3, EGFR, JAK1 and CDK4 respectively. Inhibits STAT-5 phosphorylation and T cell proliferation.

Licensing Information

Sold with the permission of AstraZeneca Ltd.

Technical Data for ZM 449829

M. Wt	182.22
Formula	C₁₃H₁₀O
Storage	Desiccate at -20°C
Purity	≥98% (HPLC)
CAS Number	4452-06-6
PubChem ID	3799
InChi Key	FOTCGZPFSUWZBN-UHFFFAOYSA-N
Smiles	C=CC(C2=CC1=CC=CC=C1C=C2)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for ZM 449829

References are publications that support the biological activity of the product.

Orange IL-2 induces a WAVE2-dependent pathway for actin reorganization that enables WASp-independent human NK cell function. J.Clin.Invest. 2011 PMID: 21383498
Brown Naphthyl ketones: a new class of janus kinase 3 inhibitors Bioorg.Med.Chem.Lett. 2000 PMID: 10741557