Zonisamide

Name: Zonisamide
Brand: Tocris Bioscience
SKU: 2625

Tocris Bioscience, part of Bio-Techne | Catalog # 2625

(1)

Citations (7)

COA / SDS

Blocks voltage-sensitive Na+ and Ca2+ channels (T-type)

Key Product Details

Chemical Name:	1,2-Benzisoxazole-3-methanesulfonamide
Purity:	≥99%
Molecular Weight:	212.22 kDa

View Full Technical Details for Zonisamide

Technical Data
Citations / Reviews (1)

Biological Activity for Zonisamide

Zonisamide is a antiepileptic that possesses a broad spectrum anticonvulsant and mechanistic profile. Blocks voltage-sensitive Na⁺ and T-type Ca²⁺ channels, stimulates BK_Ca channels, modulates GABA, glutamate and monoamine neurotransmission, inhibits lipid peroxidation and scavenges hydroxyl and nitric oxide free radicals. Displays neuroprotective and antiParkinsonian activity.

Technical Data for Zonisamide

M. Wt	212.22 kDa
Formula	C₈H₈N₂O₃S
Storage	Store at +4°C
Purity	≥99%
CAS Number	68291-97-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for Zonisamide

Solubility

Soluble Soluble to 10 mM in water and to 100 mM in DMSO

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References for Zonisamide

References are publications that support the biological activity of the product.

Sobieszek et al. Zonisamide: a new antiepileptic drug. Pol.J.Pharmacol., 2003;55:683 PMID: 14704463
Gluck et al. Novel DA releasing response of an anti-convulsant agent with possible anti-Parkinson's activity. J.Neural Transm., 2004;111:713 PMID: 15168218
Huang et al. Activation by Zonisamide, a newer antiepileptic drug, of large-conductance calcium-activated potassium channel in differentiated hippocampal neuron-derived H19-7 cells. J.Pharmacol.Exp.Ther., 2007;321:98 PMID: 17255467
Tokumaru et al. In vivo evaluation of hippocampal anti-oxidant ability of zonis. in rats. Neurochem.Res., 2000;25:1107 PMID: 11055748