1,6-Hexanediol

Name: 1,6-Hexanediol
Brand: Tocris Bioscience
SKU: 7046

Tocris Bioscience, part of Bio-Techne | Catalog # 7046

Citations (2)

COA / SDS

Tool for probing liquid-liquid phase separation

Key Product Details

Description:	Tool for probing liquid-liquid phase separation
Purity:	≥98%
Molecular Weight:	118.18

View Full Technical Details for 1,6-Hexanediol

Technical Data
Citations

Biological Activity for 1,6-Hexanediol

1,6-Hexanediol is a widely used tool to probe liquid-liquid phase separation (LLPS) in cells. Disrupts hydrophobic interaction-induced phase separation assemblies both in vitro and in vivo. Dissolves LLPS condensates, such as P bodies, but not solid-like condensates, such as protein aggregates and cytoskeletal assemblies.Typically used as a 3-10% solution (w/v). Disrupts cellular structures in yeast and alters cellular morphology in HeLa cells.

Technical Data for 1,6-Hexanediol

M. Wt	118.18
Formula	C₆H₁₄O₂
Storage	Store at RT
Purity	≥98%
CAS Number	629-11-8
PubChem ID	12374
InChi Key	XXMIOPMDWAUFGU-UHFFFAOYSA-N
Smiles	OCCCCCCO

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility for 1,6-Hexanediol

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
	water	11.82	100
	DMSO	11.82	100

Preparing Stock Solutions for 1,6-Hexanediol

The following data is based on the product molecular weight 118.18.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	8.46 mL	42.31 mL	84.62 mL
5 mM	1.69 mL	8.46 mL	16.92 mL
10 mM	0.85 mL	4.23 mL	8.46 mL
50 mM	0.17 mL	0.85 mL	1.69 mL

Molarity Calculator

Calculate the mass, volume, or concentration required for a solution.

Mass

Concentration

Volume

M. Wt*

g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Dilution Calculator

Calculate the dilution required to prepare a stock solution.

Concentration 1 (C1)

Volume 1 (V1)

Concentration 2 (C2)

Volume 2 (V2)

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

Volume (to add to vial)

Mass (in vial)

Desired Reconstitution Concentration

References for 1,6-Hexanediol

References are publications that support the biological activity of the product.

Wheeler Distinct stages in stress granule assembly and disassembly. Elife 2016 PMID: 27602576
Kroschwald Hexanediol: a chemical probe to investigate the material properties of membrane-less compartments. Matters
Shan Basal condensation of Numb and Pon complex via phase transition during Drosophila neuroblast asymmetric division. Nat.Commun. 2018 PMID: 29467404