Application Brief 1037: PTEN NanoPro Assay

Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is a tumor suppressor protein that is frequently mutated or deleted in many tumors. PTEN dephosphorylates phosphatidylinositol 3,4,5-triphosphate (PtdInsP3) inhibiting phosphoinositide 3-kinase (PI3K) activation of AKT repressing cell growth, proliferation and survival. Recent studies show that PTEN phosphorylation alters its stability and function.