Tools for Investigating Immune Checkpoint Targets Product Guide
Product Guides and ListingsImmune cell activation is regulated by a delicate balance of stimulatory and inhibitory signals received through specific ligand-receptor interactions known as immune checkpoints. Stimulatory signals promote immune cell activation to protect the host from invading pathogens and developing malignancies, while inhibitory signals suppress immune cell activation to regulate the magnitude and duration of immune responses. As a way to evade immune detection and destruction, tumor cells frequently exploit immune checkpoint pathways by up-regulating the expression of ligands that activate inhibitory receptors on different immune cell types. As a result, researchers have focused on trying to improve anti-tumor immune responses using either antagonists of inhibitory immune checkpoint receptors or agonists of stimulatory receptors aimed at restoring or enhancing the immune response.
Bio-Techne offers a large selection of R&D Systems™ bioactive recombinant proteins for immune checkpoint research, along with antibodies for blocking or detecting immune checkpoint targets, and single and multianalyte immunoassays for quantifying soluble immune checkpoint proteins. Download this guide to discover the key benefits of Bio-Techne’s immune checkpoint products and learn how these products can be used to help advance your immune checkpoint research.
Immune checkpoint products outlined in this guide include:
- Immune Checkpoint Proteins
- Avi-tag and Amine-Labeled Biotinylated Proteins
- Fluorokines™ Fluorescent-labeled Proteins
- Animal-free Preclinical Proteins
- GMP-grade Proteins for Cell Therapy Research
- Custom Protein Services
- Blocking/Neutralizing Immune Checkpoint Antibodies
- Biosimilar Antibodies
- Custom Antibody Services
- Immunoassays for Immune Checkpoint Research
- Luminex® Assays
- Simple Plex™ Assays on the Ella™ Platform
