Webinar: Interrogating Cell Signaling Pathways in iPSC-Derived Microglia to Understand Alzheimer's Pathology

Microglia, the brain's resident immune cells, play a critical role in mediating inflammatory responses within the central nervous system (CNS). They also contribute to recognizing and eliminating foreign invaders, as well as repairing damaged CNS tissue after injury.

TREM2, a receptor protein expressed on the microglia membranes, has emerged as a promising therapeutic target for Alzheimer’s disease. However, studying the function of TREM2 and its downstream signaling pathways using human-relevant in vitro models has historically been challenging. By differentiating induced pluripotent stem cells (iPSCs) into specialized microglial cells, it is now possible to investigate these essential signaling pathways in detail.

In this webinar, we will show how we used iPSC-derived microglia to investigate mechanisms of TREM2 signaling through high-throughput, multiplexed capillary western analysis with Simple Western™ Technology and antibodies rigorously validated for the platform. Also, we will introduce the Leo™ System, the latest addition to the Simple Western family, capable of processing up to 100 samples in a single 3-hour run using minimal sample volumes.