Ataxin-3 Products
Ataxin-3, also known as Machado-Joseph Disease (MJD) Protein 1 and Spinocerebellar Ataxia Type 3, is a 364 amino acid (aa), ubiquitously expressed cytoplasmic and nuclear protein with a predicted molecular weight of 42 kDa. Ataxin-3 functions as a deubiquitinating enzyme. Human Ataxin-3 shares 87% and 86% aa sequence identity with mouse and rat Ataxin-3, respectively. Full-length Ataxin-3 contains an N-terminal Josephin domain, two Ubiquitin interacting motifs, and a variable C-terminus consisting of a polyglutamine stretch and tail. As a deubiquitinating enzyme, Ataxin-3 plays a critical role in affecting the ubiquitination status of proteins for quality control and other cellular pathways. In turn, the ubiquitination of Ataxin-3 is was shown to enhance its capacity to cleave Ubiquitin chains. By opposing the actions of the Ubiquitin-conjugating (E2) enzyme UbE2W, Ataxin-3 is believed to control the activity of the Ubiquitin ligase (E3) C-terminus of Hsc70 Interacting Protein (CHIP). CHIP binds to protein chaperones and represents an important molecular link between the chaperone and Ubiquitin-proteasome system. Expression of murine Ataxin-3 is thought to be important for myogenesis, an effect that is dependent on the regulation of Integrin alpha 5 levels. Mutations in the ATXN3 gene are the cause of MJD, also known as spinocerebellar ataxia 3, an autosomal dominant neurodegenerative disorder characterized by nuclear aggregation of Ataxin-3 molecules featuring an expanded polyglutamine tract.
11 results for "Ataxin-3" in Products
11 results for "Ataxin-3" in Products
Ataxin-3 Products
Ataxin-3, also known as Machado-Joseph Disease (MJD) Protein 1 and Spinocerebellar Ataxia Type 3, is a 364 amino acid (aa), ubiquitously expressed cytoplasmic and nuclear protein with a predicted molecular weight of 42 kDa. Ataxin-3 functions as a deubiquitinating enzyme. Human Ataxin-3 shares 87% and 86% aa sequence identity with mouse and rat Ataxin-3, respectively. Full-length Ataxin-3 contains an N-terminal Josephin domain, two Ubiquitin interacting motifs, and a variable C-terminus consisting of a polyglutamine stretch and tail. As a deubiquitinating enzyme, Ataxin-3 plays a critical role in affecting the ubiquitination status of proteins for quality control and other cellular pathways. In turn, the ubiquitination of Ataxin-3 is was shown to enhance its capacity to cleave Ubiquitin chains. By opposing the actions of the Ubiquitin-conjugating (E2) enzyme UbE2W, Ataxin-3 is believed to control the activity of the Ubiquitin ligase (E3) C-terminus of Hsc70 Interacting Protein (CHIP). CHIP binds to protein chaperones and represents an important molecular link between the chaperone and Ubiquitin-proteasome system. Expression of murine Ataxin-3 is thought to be important for myogenesis, an effect that is dependent on the regulation of Integrin alpha 5 levels. Mutations in the ATXN3 gene are the cause of MJD, also known as spinocerebellar ataxia 3, an autosomal dominant neurodegenerative disorder characterized by nuclear aggregation of Ataxin-3 molecules featuring an expanded polyglutamine tract.
Recombinant Monoclonal Antibody
Reactivity: | Human, Mouse, Rat |
Details: | Rabbit IgG Monoclonal Clone #HL1909 |
Applications: | IHC, WB, ICC/IF |
Reactivity: | Human, Mouse, Rat |
Details: | Rabbit IgG Polyclonal |
Applications: | IHC, WB, ICC/IF |
Reactivity: | Human |
Details: | Rabbit IgG Polyclonal |
Applications: | WB, ICC/IF, IP, KO |
Applications: | PAGE |
Recombinant Monoclonal Antibody
Reactivity: | Human, Mouse, Rat |
Details: | Rabbit IgG Monoclonal Clone #S04-1I8 |
Applications: | WB |
Reactivity: | Human |
Details: | Rabbit IgG Polyclonal |
Applications: | IHC, WB, IP |
Reactivity: | Human, Mouse |
Details: | Rabbit IgG Polyclonal |
Applications: | WB, ICC/IF |
Reactivity: | Human |
Details: | Rabbit Polyclonal |
Applications: | WB |
Applications: | AC |
Reactivity: | Human |
Details: | Rabbit IgG Polyclonal |
Applications: | ICC/IF |
Reactivity: | Mouse, Rat |
Details: | Rabbit IgG Monoclonal Clone #7B2I1 |
Applications: | WB, ELISA |