B7-H3 Products
B7-H3 is an immunoglobulin superfamily protein that is expressed by osteoblasts, fibroblasts, ciliated respiratory epithelial cells, anterior pituitary progenitor cells, first trimester extravillous trophoblasts, and multiple tumor cells. It is induced on activated dendritic cells (DC), skeletal muscle myocytes, and monocytes. B7-H3 can both stimulate and inhibit immune cell activation.
As a co-stimulator, B7-H3 augments macrophage activation and promotes proliferation and cytokine secretion by CD4+ and CD8+ T cells. As a co-inhibitor, tumor cell B7-H3 blocks the cytolytic activity of NK cells, limits cytokine production by activated T cells, and imparts an immunosuppressive phenotype to dendritic cells. B7-H3 can interact with TREML2/TLT-2 to enhance T cell activation including the CD8+ T cell-mediated lysis of tumor cells.
Products:
298 results for "B7-H3" in Products
298 results for "B7-H3" in Products
B7-H3 Products
B7-H3 is an immunoglobulin superfamily protein that is expressed by osteoblasts, fibroblasts, ciliated respiratory epithelial cells, anterior pituitary progenitor cells, first trimester extravillous trophoblasts, and multiple tumor cells. It is induced on activated dendritic cells (DC), skeletal muscle myocytes, and monocytes. B7-H3 can both stimulate and inhibit immune cell activation.
As a co-stimulator, B7-H3 augments macrophage activation and promotes proliferation and cytokine secretion by CD4+ and CD8+ T cells. As a co-inhibitor, tumor cell B7-H3 blocks the cytolytic activity of NK cells, limits cytokine production by activated T cells, and imparts an immunosuppressive phenotype to dendritic cells. B7-H3 can interact with TREML2/TLT-2 to enhance T cell activation including the CD8+ T cell-mediated lysis of tumor cells.
Products:
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Simple Western, Flow, IHC, CyTOF-ready, +1 More |
| Source: | NS0 |
| Accession #: | Q5ZPR3 |
| Applications: | BA |
| Source: | NS0 |
| Accession #: | NP_079516 |
| Applications: | BA |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #185504 |
| Applications: | WB, Flow, CyTOF-ready, KO |
Biotinylated
| Source: | CHO |
| Accession #: | NP_079516.1 |
| Applications: | BA, BA |
| Source: | NS0 |
| Accession #: | NP_079516 |
| Applications: | BA |
| Sensitivity: | 0.274 ng/mL |
| Applications: | ELISA |
| Assay Range: | 0.781 - 50 ng/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma, Urine) |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, IHC |
| Source: | NS0 |
| Accession #: | Q8VE98.1 |
| Applications: | BA |
Biotinylated long-form B7-H3 (4Ig)/B7-H3b
| Source: | HEK293 |
| Accession #: | Q5ZPR3-1 |
| Applications: | BA, BA |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #185504 |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ICC/IF, KO |
![Knockout Validated: B7-H3/CD276 Antibody [NBP1-88966]](https://resources.bio-techne.com/images/products/B7-H3-CD276-Antibody-Knockout-Validated-NBP1-88966-img0016.jpg "Knockout Validated: B7-H3/CD276 Antibody [NBP1-88966]")
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Neut |
Recombinant Monoclonal Antibody.
| Reactivity: | Mouse |
| Details: | Rabbit IgG Monoclonal Clone #2741E |
| Applications: | Flow, ICC |
| Reactivity: | Human |
| Details: | Mouse Monoclonal Clone #1090036 |
| Applications: | WB, Simple Western, IHC, mIF |
| Source: | NS0 |
| Accession #: | NP_079516 |
| Applications: | BA |
| Source: | CHO |
| Accession #: | Q5ZPR3.1 |
| Applications: | BA, BA, Bind |
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Human IgG1 Monoclonal Clone #enoblituzumab |
| Applications: | ELISA, Flow, Func |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #185504 |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #185504 |
| Applications: | Flow |
| Source: | NS0 |
| Accession #: | Q7TPB4.1 |
| Applications: | BA |
| Source: | NS0 |
| Accession #: | Q8VE98.1 |
| Applications: | BA |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #185504 |
| Applications: | Flow |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #185504 |
| Applications: | Flow |
