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Cathepsin D Products

Cathepsin D is a lysosomal aspartic protease of the pepsin family. Human Cathepsin D is synthesized as a precursor protein, consisting of a signal peptide (residues 1 - 18), a propeptide (residues 19 - 64), and a mature chain (residues 65 - 412). The mature chain can be processed further to the light (residues 65 - 161) and heavy (residues 169 - 412) chains. It is expressed in most cells and over expressed in breast cancer cells. Cathepsin D is a major enzyme in protein degradation in lysosomes, and also involved in the presentation of antigenic peptides. Mice deficient in Cathepsin D have been shown to develop a progressive atrophy of the intestinal mucosa, a massive destruction of lymphoid organs, and a profound neuronal ceroid lipofucinosis, indicating that Cathepsin D is essential for proteolysis of proteins regulating cell growth and tissue homeostasis. Cathepsin D secreted from human prostate carcinoma cells are responsible for the generation of angiostatin, a potent endogenous inhibitor of angiogenesis.

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95 results for "Cathepsin D" in Products

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95 results for "Cathepsin D" in Products

Cathepsin D Products

Cathepsin D is a lysosomal aspartic protease of the pepsin family. Human Cathepsin D is synthesized as a precursor protein, consisting of a signal peptide (residues 1 - 18), a propeptide (residues 19 - 64), and a mature chain (residues 65 - 412). The mature chain can be processed further to the light (residues 65 - 161) and heavy (residues 169 - 412) chains. It is expressed in most cells and over expressed in breast cancer cells. Cathepsin D is a major enzyme in protein degradation in lysosomes, and also involved in the presentation of antigenic peptides. Mice deficient in Cathepsin D have been shown to develop a progressive atrophy of the intestinal mucosa, a massive destruction of lymphoid organs, and a profound neuronal ceroid lipofucinosis, indicating that Cathepsin D is essential for proteolysis of proteins regulating cell growth and tissue homeostasis. Cathepsin D secreted from human prostate carcinoma cells are responsible for the generation of angiostatin, a potent endogenous inhibitor of angiogenesis.

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Applications: ELISA
Applications: IHC, WB, ICC/IF, IP
Reactivity: Human, Mouse

Recombinant Monoclonal Antibody.

Applications: IHC, WB
Reactivity: Human
Applications: IHC, WB, ELISA, IP
Reactivity: Human
Applications: IHC, WB, ELISA, CyTOF-ready
Reactivity: Human
Applications: WB, ELISA, IP
Reactivity: Mouse

Recombinant Monoclonal Antibody

Applications: IHC, WB
Reactivity: Human

Recombinant Monoclonal Antibody

Applications: ELISA
Applications: WB, ELISA, IP
Reactivity: Mouse

Recombinant Monoclonal Antibody

Applications: IHC, WB
Reactivity: Human

Recombinant Monoclonal Antibody

Applications: WB
Applications: ELISA
Applications: ELISA
Catalog #: NBP2-54844
Applications: AC
Applications: IHC, WB
Reactivity: Human

Recombinant Monoclonal Antibody

Applications: IHC, WB
Reactivity: Human

Recombinant Monoclonal Antibody

Applications: WB, ELISA, IP
Reactivity: Mouse

Recombinant Monoclonal Antibody

Applications: IHC, WB
Reactivity: Human

Recombinant Monoclonal Antibody

Applications: WB, ELISA, IP
Reactivity: Mouse

Recombinant Monoclonal Antibody

Applications: WB, ELISA, IP
Reactivity: Mouse

Recombinant Monoclonal Antibody

Applications: IHC, WB
Reactivity: Human

Recombinant Monoclonal Antibody

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