ENPP-2/Autotaxin Products
ENPP-2, also known as Autotaxin, belongs to the ectonucleotide pyrophosphatase/phosphodiesterase (NPP) family. Some NPPs hydrolyze phosphates from nucleotides and their derivatives. ENPP-2 shares 40 - 50% identity to ENPP1 & 3, all of which contain a N-terminal intracellular domain, a single transmembrane domain and a large extracellular domain that includes a catalytic domain, two somatomedin-B-like domains, and a C-terminal nuclease-like domain. Unlike ENPP-1 and ENPP-3, ENPP-2 has weak activity against nucleotides, but exhibits a lysophospholipase D activity which allows the formation of lysophosphatidic acid (LPA) and choline from lysophosphatidylcholine. The hydrolysis of nucleotides and lysophospholipids by ENPP-2 is mediated by a single catalytic site. Evidence shows LPA and sphingosine 1-phosphate to be specific inhibitors of ENPP-2. ENPP-2 was originally found to stimulate tumor cell motility and has since been found to enhance tumor invasion and metastasis and to be up-regulated in several types of carcinomas including breast and lung.
91 results for "ENPP-2/Autotaxin" in Products
91 results for "ENPP-2/Autotaxin" in Products
ENPP-2/Autotaxin Products
ENPP-2, also known as Autotaxin, belongs to the ectonucleotide pyrophosphatase/phosphodiesterase (NPP) family. Some NPPs hydrolyze phosphates from nucleotides and their derivatives. ENPP-2 shares 40 - 50% identity to ENPP1 & 3, all of which contain a N-terminal intracellular domain, a single transmembrane domain and a large extracellular domain that includes a catalytic domain, two somatomedin-B-like domains, and a C-terminal nuclease-like domain. Unlike ENPP-1 and ENPP-3, ENPP-2 has weak activity against nucleotides, but exhibits a lysophospholipase D activity which allows the formation of lysophosphatidic acid (LPA) and choline from lysophosphatidylcholine. The hydrolysis of nucleotides and lysophospholipids by ENPP-2 is mediated by a single catalytic site. Evidence shows LPA and sphingosine 1-phosphate to be specific inhibitors of ENPP-2. ENPP-2 was originally found to stimulate tumor cell motility and has since been found to enhance tumor invasion and metastasis and to be up-regulated in several types of carcinomas including breast and lung.
Sensitivity: | 0.157 ng/mL |
Applications: | ELISA |
Assay Range: | 0.781 - 50 ng/mL (Cell Culture Supernates, Serum, Heparin Plasma, Urine, Human Milk) |
Simple Plex Human ENPP-2/Autotaxin assay kit for use on Ella instrument. Contains cartridge, sample diluent SD13, and wash buffer.
Applications: | Simple Plex |
Create your custom Simple Plex cartridge for up to 8 targets. Choose from more than 250 targets across multiple species.
Source: | NS0 |
Accession #: | Q13822 |
Applications: | EnzAct |
Source: | NS0 |
Accession #: | Q9R1E6 |
Applications: | EnzAct |
Applications: | ELISA |
Assay Range: | 78.1 - 5,000 pg/mL |
Applications: | ELISA |
Reactivity: | Human |
Details: | Goat IgG Polyclonal |
Applications: | WB, IP |
Control for use with Human ENPP-2/Autotaxin Simple Plex Cartridge Kit
Applications: | Ctrl, Simple Plex |
Reactivity: | Human, Mouse, Rat, Monkey |
Details: | Rabbit Polyclonal |
Applications: | IHC, WB, ELISA, IP, DB |
Reactivity: | Human |
Details: | Rabbit IgG Polyclonal |
Applications: | IHC |
Applications: | ELISA |
Applications: | WB |
Reactivity: | Human |
Details: | Rabbit IgG Polyclonal |
Applications: | WB, ICC/IF |
Reactivity: | Mouse |
Details: | Rabbit IgG Polyclonal |
Applications: | IHC, ELISA |
Reactivity: | Rat |
Details: | Mouse IgG1 kappa Monoclonal Clone #C2 |
Applications: | IHC, WB, ICC/IF |
Reactivity: | Human |
Details: | Rabbit IgG Polyclonal |
Applications: | WB |
Reactivity: | Human |
Details: | Rabbit IgG Polyclonal |
Applications: | WB, ELISA |
Reactivity: | Human |
Details: | Rabbit IgG Polyclonal |
Applications: | ICC/IF |
Reactivity: | Human, Mouse |
Details: | Rabbit IgG Polyclonal |
Applications: | IHC, WB, ICC/IF, Flow |
Reactivity: | Human |
Details: | Mouse IgG1 kappa Monoclonal Clone #A4 |
Applications: | WB |
Applications: | AC |
Reactivity: | Human |
Details: | Rabbit IgG Polyclonal |
Applications: | IHC |
Reactivity: | Mouse |
Details: | Rabbit IgG Polyclonal |
Applications: | IHC, ELISA |
Reactivity: | Mouse |
Details: | Rabbit IgG Polyclonal |
Applications: | IHC, ELISA |