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Ikaros Products

Ikaros (also LyF1) is a 60 kDa member of the C2H2-type zinc-finger protein family. It is found in both T and B cells and serves as a context-dependent activator or repressor of genes. Human Ikaros is 519 amino acids (aa) in length. It possesses two zinc-finger domains, one at the N-terminus that contains four zinc-finger motifs (aa 117-224) and one at the C-terminus that contains two zinc-finger motifs (aa 462-514). The C-terminal motifs mediate homo- or heterodimerization, while the N-terminal motifs bind DNA. Multiple splice forms of 37 kDa to 47 kDa exist (Ikaros 2-8) with reduced numbers of N-terminal zinc-finger motifs. At least three are needed for DNA binding, and a heterodimer with a two-motif monomer is suggested to be transcriptionally inert. Over aa 427-519 (which are not spliced), human Ikaros shows 88% aa identity to mouse Ikaros.

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15 results for "Ikaros" in Products

15 results for "Ikaros" in Products

Ikaros Products

Ikaros (also LyF1) is a 60 kDa member of the C2H2-type zinc-finger protein family. It is found in both T and B cells and serves as a context-dependent activator or repressor of genes. Human Ikaros is 519 amino acids (aa) in length. It possesses two zinc-finger domains, one at the N-terminus that contains four zinc-finger motifs (aa 117-224) and one at the C-terminus that contains two zinc-finger motifs (aa 462-514). The C-terminal motifs mediate homo- or heterodimerization, while the N-terminal motifs bind DNA. Multiple splice forms of 37 kDa to 47 kDa exist (Ikaros 2-8) with reduced numbers of N-terminal zinc-finger motifs. At least three are needed for DNA binding, and a heterodimer with a two-motif monomer is suggested to be transcriptionally inert. Over aa 427-519 (which are not spliced), human Ikaros shows 88% aa identity to mouse Ikaros.

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Applications: IHC, WB, Simple Western
Reactivity: Human
Applications: WB, Simple Western, ChIP, CyTOF-ready, ICC, ICFlow
Reactivity: Human
Applications: WB, ELISA, MA, AP
Applications: IHC, ICC/IF
Reactivity: Human
Applications: IHC, WB
Reactivity: Human, Mouse, Rat

Recombinant Monoclonal Antibody

Applications: WB, ICC/IF, Flow, IP
Reactivity: Human, Mouse
Applications: WB, ICC/IF, ChIP
Reactivity: Human, Mouse

Recombinant Monoclonal Antibody

Applications: WB
Reactivity: Human, Mouse
Applications: IHC, ELISA
Reactivity: Human
Applications: WB, ELISA
Reactivity: Human
Applications: AC
Applications: WB
Reactivity: Mouse
Applications: ELISA, Flow
Reactivity: Human

Recombinant monoclonal antibody expressed in HEK293F cells

Applications: WB
Applications: AC
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