IL-18/IL-1F4 Products
IL-18 (Interleukin-18) is secreted by macrophages, dendritic cells, and epithelial cells. Circulating mature IL-18 is sequestered by soluble IL-18 binding proteins (IL-18 BP) that inhibit IL-18 bioactivity. IL-18 signals through a receptor complex that contains IL-18 R alpha IL-18 R beta. It synergizes with other cytokines to activate NK, Th1, and Th17 cells and to increase the production of IFN-gamma. It can also promote Th2 cytokine release which reduces the effectiveness of antiviral responses. Increased levels of active IL-18 contribute to the severity of autoimmunity and hypertension, while deficiency of IL-18 results in symptoms of metabolic syndrome. In cancer, IL-18 stimulates Th1 and NK cells to target tumor cells, but it can also promote angiogenesis, metastasis, and tumor cell immune evasion.
346 results for "IL-18/IL-1F4" in Products
346 results for "IL-18/IL-1F4" in Products
IL-18/IL-1F4 Products
IL-18 (Interleukin-18) is secreted by macrophages, dendritic cells, and epithelial cells. Circulating mature IL-18 is sequestered by soluble IL-18 binding proteins (IL-18 BP) that inhibit IL-18 bioactivity. IL-18 signals through a receptor complex that contains IL-18 R alpha IL-18 R beta. It synergizes with other cytokines to activate NK, Th1, and Th17 cells and to increase the production of IFN-gamma. It can also promote Th2 cytokine release which reduces the effectiveness of antiviral responses. Increased levels of active IL-18 contribute to the severity of autoimmunity and hypertension, while deficiency of IL-18 results in symptoms of metabolic syndrome. In cancer, IL-18 stimulates Th1 and NK cells to target tumor cells, but it can also promote angiogenesis, metastasis, and tumor cell immune evasion.
| Sensitivity: | 5.15 pg/mL |
| Applications: | ELISA |
| Assay Range: | 15.6 - 1,000 pg/mL (Cell Culture Supernates, Serum, EDTA Plasma, Heparin Plasma, Saliva, Urine) |
Simple Plex Human IL-18/IL-1F4 assay kit for use on Ella instrument. Contains cartridge, sample diluent SD13, and wash buffer.
| Applications: | Simple Plex |
| Assay Range: | 11.7 - 750 pg/mL |
| Applications: | ELISA |
Contains 4 membranes - each spotted in duplicate with 36 different cytokine antibodies
| Sensitivity: | 25 pg/mL |
| Applications: | ELISA |
| Assay Range: | 25.6 - 1,000 pg/mL |
Analyzed by SEC-MALS
| Source: | E. coli |
| Accession #: | Q14116 |
| Applications: | BA |
Human IL-18/IL-1F4 Quantikine ELISA Kit is now available!
| Sensitivity: | 12.5 pg/mL |
| Applications: | ELISA |
| Assay Range: | 25.6 - 1,000 pg/mL |
| Assay Range: | 46.9 - 3,000 pg/mL |
| Applications: | ELISA |
Design and order Simple Plex cartridges tailor made to meet your needs with customizable Simple Plex Assay panels for the Ella platform.
| Applications: | Simple Plex |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #74801 |
| Applications: | ICFlow |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #125-2H |
| Applications: | IP, Neut |
Luminex High Performance Assays go through rigorous development, validation, and quality control testing to ensure you are getting the best performance out of your multiplex assay. Panels are customizable so you can order a selection of the analytes or the entire panel.
| Source: | E. coli |
| Accession #: | P70380 |
| Applications: | BA |
Control for use with Human and Non-Human Primate IL-18/IL-1F4 Simple Plex Cartridge Kit
| Applications: | Ctrl, Simple Plex |
| Reactivity: | Human, Rhesus Macaque |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Simple Western, ELISA, ICC, KO, +1 More |
| Source: | E. coli |
| Accession #: | P97636.1 |
| Applications: | BA |
| Reactivity: | Rat |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Neut |
| Reactivity: | Mouse |
| Details: | Rat IgG2a Monoclonal Clone #74 |
| Applications: | IP |
| Reactivity: | Human |
| Details: | Rat IgG2a Monoclonal Clone #159-12B |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, Simple Western, KO |
Luminex High Performance Assays go through rigorous development, validation, and quality control testing to ensure you are getting the best performance out of your multiplex assay. Panels are customizable so you can order a selection of the analytes or the entire panel.
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #74801 |
| Applications: | WB, CyTOF-ready, ICFlow, KO |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #25-2G |
| Applications: | WB |
For use with catalog number DL180
| Applications: | Ctrl |