Mcl-1 Products
Mcl-1 (Myeloid Cell Leukemia 1) is a member of the Bcl-2 family of proteins. Alternative splicing results in two distinct isoforms: Mcl-1L (long) enhances cell survival by inhibiting apoptosis, while Mcl-1S (short) promotes apoptosis. The elimination of Mcl-1L is an early and required step for DNA damage-induced apoptosis. Degradation of Mcl-1L is regulated by polyubiquitination, which targets Mcl-1L to the proteasome pathway.
61 results for "Mcl-1" in Products
61 results for "Mcl-1" in Products
Mcl-1 Products
Mcl-1 (Myeloid Cell Leukemia 1) is a member of the Bcl-2 family of proteins. Alternative splicing results in two distinct isoforms: Mcl-1L (long) enhances cell survival by inhibiting apoptosis, while Mcl-1S (short) promotes apoptosis. The elimination of Mcl-1L is an early and required step for DNA damage-induced apoptosis. Degradation of Mcl-1L is regulated by polyubiquitination, which targets Mcl-1L to the proteasome pathway.
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #542808 |
| Applications: | WB, IHC, KO |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, IP |
![Western Blot: Mcl-1 Antibody [NB100-56146]](https://resources.bio-techne.com/images/products/MCL1-Antibody-Western-Blot-NB100-56146-img0002.jpg "Western Blot: Mcl-1 Antibody [NB100-56146]")
Contains 8 membranes - each spotted in duplicate with 21 different apoptosis antibodies
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #CL1128 |
| Applications: | IHC, WB, ICC/IF |
![Western Blot: Mcl-1 Antibody (CL1128) [NBP2-52968]](https://resources.bio-techne.com/images/products/Mcl-1-Antibody-CL1128-Western-Blot-NBP2-52968-img0005.jpg "Western Blot: Mcl-1 Antibody (CL1128) [NBP2-52968]")
| Reactivity: | Human |
| Details: | Sheep IgG Polyclonal |
| Applications: | WB, Simple Western, KO |
| Source: | E. coli |
| Applications: | WB |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #OTI10F6 |
| Applications: | IHC, WB, ICC/IF, Flow |
![Western Blot: Mcl-1 Antibody (OTI10F6) [NBP2-45773]](https://resources.bio-techne.com/images/products/Mcl-1-Antibody-OTI10F6-Western-Blot-NBP2-45773-img0009.jpg "Western Blot: Mcl-1 Antibody (OTI10F6) [NBP2-45773]")
Recombinant Monoclonal Antibody
| Reactivity: | Human, Mouse, Rat, Canine, Feline |
| Details: | Rabbit IgG Monoclonal Clone #HL1544 |
| Applications: | IHC, WB |
Recombinant Monoclonal Antibody.
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #SI16-04 |
| Applications: | IHC, WB, ICC/IF, Flow, IP |
![Western Blot: Mcl-1 Antibody (SI16-04) [NBP2-67400]](https://resources.bio-techne.com/images/products/Mcl-1-Antibody-SI16-04-Western-Blot-NBP2-67400-img0010.jpg "Western Blot: Mcl-1 Antibody (SI16-04) [NBP2-67400]")
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #602901 |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #8C6 |
| Applications: | IHC, WB, ELISA, ICC/IF |
![Western Blot: Mcl-1 Antibody (8C6)BSA Free [NB100-2194]](https://resources.bio-techne.com/images/products/Mcl-1-Antibody-8C6D4B1-Western-Blot-NB100-2194-img0008.jpg "Western Blot: Mcl-1 Antibody (8C6)BSA Free [NB100-2194]")
Recombinant Monoclonal Antibody
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #S04-3A4 |
| Applications: | WB, ICC/IF |
![Western Blot: Mcl-1 Antibody (S04-3A4) [NBP3-19546]](https://resources.bio-techne.com/images/products/Mcl-1-Antibody-S04-3A4-Western-Blot-NBP3-19546-img0002.jpg "Western Blot: Mcl-1 Antibody (S04-3A4) [NBP3-19546]")
Downregulates Bcl-2 and Mcl-1; pro-apoptotic
| Chemical Name: | (-)-1,1',6,6',7,7'-Hexahydroxy-3,3'-dimethyl-5,5'-bis(1-methylethyl)-[2,2'-binaphthalene]-8,8'-dicarboxaldehyde |
| Purity: | ≥98% (HPLC) |
Potent and selective kinesin spindle protein (KSP) inhibitor; induces Mcl-1 degradation
| Alternate Names: | Filanesib |
| Chemical Name: | (2S)-2-(3-Aminopropyl)-5-(2,5-difluorophenyl)-N-methoxy-N-methyl-2-phenyl-1,3,4-thiadiazole-3(2H)-carboxamide trifluoroacetate |
| Purity: | ≥98% (HPLC) |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ICC/IF, ELISA |
| Applications: | PAGE, SPR |
![SDS-PAGE: Recombinant Human Mcl-1 His Protein [NBP2-51510]](https://resources.bio-techne.com/images/products/Recombinant-Human-Mcl-1-Protein-SDS-Page-NBP2-51510-img0001.jpg "SDS-PAGE: Recombinant Human Mcl-1 His Protein [NBP2-51510]")
| Applications: | AC |
Inhibitor of Bcl-2 family members; antiapoptotic
| Alternate Names: | GX15-070 |
| Chemical Name: | 2-[2-[(3,5-Dimethyl-1H-pyrrol-2-yl)methylene)-3-methoxy-2H-pyrrol-5-yl]-1H-indole methanesulfonate |
| Purity: | ≥98% (HPLC) |
| Applications: | AC |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC |
![Immunohistochemistry-Paraffin: Mcl-1 Antibody [NBP1-90006]](https://resources.bio-techne.com/images/products/Mcl-1-Antibody-Immunohistochemistry-Paraffin-NBP1-90006-img0003.jpg "Immunohistochemistry-Paraffin: Mcl-1 Antibody [NBP1-90006]")
| Applications: | ELISA |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, IP |
| Applications: | ELISA |
| Applications: | AC |