NFkB2 Products
NFkB1 (NFkB p50) and NFkB2 (NFkB p52) are class I members of the Rel/NFkB family of transcription factors that also includes RelA, c-Rel and RelB. Rel/NFkB members regulate expression of genes that participate in immune, apoptotic and oncogenic processes. Class I members lack a C-terminal transcriptional activation segment found in class II members, but contain an RHD (Rel homology domain) that mediates DNA binding, nuclear localization and dimerization. NFkB1 and NFkB2 105 and 100 kDa precursors are proteolytically cleaved to 50 and 52 kDa active subunits, respectively. NFkB is predominantly localized in the cytoplasm as a complex with inhibitory IkB proteins and is released and translocated to the nucleus after phosphorylation of IkB.
24 results for "NFkB2" in Products
24 results for "NFkB2" in Products
NFkB2 Products
NFkB1 (NFkB p50) and NFkB2 (NFkB p52) are class I members of the Rel/NFkB family of transcription factors that also includes RelA, c-Rel and RelB. Rel/NFkB members regulate expression of genes that participate in immune, apoptotic and oncogenic processes. Class I members lack a C-terminal transcriptional activation segment found in class II members, but contain an RHD (Rel homology domain) that mediates DNA binding, nuclear localization and dimerization. NFkB1 and NFkB2 105 and 100 kDa precursors are proteolytically cleaved to 50 and 52 kDa active subunits, respectively. NFkB is predominantly localized in the cytoplasm as a complex with inhibitory IkB proteins and is released and translocated to the nucleus after phosphorylation of IkB.
Reactivity: | Human |
Details: | Mouse IgG1 Monoclonal Clone #291319 |
Applications: | WB, ChIP, ICC |
Reactivity: | Human |
Details: | Rabbit IgG Polyclonal |
Applications: | IHC, WB, ICC/IF, Simple Western, KD |
Reactivity: | Human |
Details: | Mouse IgG1 Monoclonal Clone #CL8266 |
Applications: | IHC |
Reactivity: | Human, Mouse |
Details: | Rabbit IgG Polyclonal |
Applications: | IHC, WB, ICC/IF |
Recombinant Monoclonal Antibody
Reactivity: | Human, Mouse, Rat |
Details: | Rabbit IgG Monoclonal Clone #4K3V3 |
Applications: | IHC, WB |
Reactivity: | Human, Mouse |
Details: | Rabbit IgG Polyclonal |
Applications: | WB, KO |
Reactivity: | Human, Mouse, Rat |
Details: | Rabbit IgG Polyclonal |
Applications: | WB, ICC/IF, KO |
Reactivity: | Human, Mouse, Rat |
Details: | Rabbit IgG Monoclonal Clone #5J6H9 |
Applications: | WB, ELISA |
Reactivity: | Mouse |
Details: | Rabbit IgG Monoclonal Clone #1J7E2 |
Applications: | WB, ELISA |
Applications: | ELISA |
Applications: | AC |
Proteasome and calpain inhibitor. Inhibits NF-κB activation
Alternate Names: | Z-LLL-al,Z-Leu-Leu-Leu-CHO |
Chemical Name: | N-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-L-leucinamide |
Purity: | ≥95% (HPLC) |
Inhibits TNF-induced NF-κB activation
Chemical Name: | 4-[(1E)-2-(3,5-Dihydroxyphenyl)ethenyl]-1,2-benzenediol |
Purity: | ≥98% (HPLC) |
Contains 4 membranes-each spotted in duplicate with 41 different proteins and 4 serine or tyrosine phosphorylation sites antibodies
Inhibits RNAPII-mediated transcription; antitumor, anti-inflammatory and immunosuppressive
Chemical Name: | (3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-3b,4,4a,6,6a,7a,7b,8b,9,10-Decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1(3H)-one |
Purity: | ≥98% (HPLC) |
Inhibits TNF-α-induced NF-κB activation
Chemical Name: | (9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid |
Purity: | ≥99% (HPLC) |
Antitumor and anti-HIV agent; activates NF-κB. Also TGR5 agonist
Chemical Name: | (+)-(3β)-3-Hydroxylup-20(29)-en-28-oic acid |
Blocks NF-κB activation; also anti-inflammatory and antioxidant
Chemical Name: | 5,3'-Diallyl-2,4'-dihydroxybiphenyl |
Purity: | ≥98% (HPLC) |
NF-κB and AP-1 dual inhibitor
Chemical Name: | N-[3,5-Bis(trifluoromethyl)phenyl]-2-chloro-4-(trifluoromethyl)-5-pyrimidinecarboxamide |
Purity: | ≥99% (HPLC) |
Inhibitor of NF-κB activation; anti-inflammatory
Chemical Name: | (2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-phenyl-2-propen-1-one |
Purity: | ≥98% (HPLC) |
Inhibits NF-κB activation
Chemical Name: | (4β,5β,6β,22R)-5,6-Epoxy-4,22,27-trihydroxy-1-oxoergosta-2,24-dien-26-oic acid δ-lactone |
Purity: | ≥98% (HPLC) |
Inhibitor of NF-κB activation; also inhibits SXC and folate transporter 1
Chemical Name: | 5-[[4-(2-Pyridylsulfamoyl)phenyl]azo]salicylic acid |
Purity: | ≥97% (HPLC) |
Specific inhibitor of NF-κB activation
Alternate Names: | CAPE |
Chemical Name: | 3-(3,4-Dihydroxyphenyl)-2-propenoic acid 2-phenylethyl ester |
Purity: | ≥98% (HPLC) |