NFkB2 Products
NFkB1 (NFkB p50) and NFkB2 (NFkB p52) are class I members of the Rel/NFkB family of transcription factors that also includes RelA, c-Rel and RelB. Rel/NFkB members regulate expression of genes that participate in immune, apoptotic and oncogenic processes. Class I members lack a C-terminal transcriptional activation segment found in class II members, but contain an RHD (Rel homology domain) that mediates DNA binding, nuclear localization and dimerization. NFkB1 and NFkB2 105 and 100 kDa precursors are proteolytically cleaved to 50 and 52 kDa active subunits, respectively. NFkB is predominantly localized in the cytoplasm as a complex with inhibitory IkB proteins and is released and translocated to the nucleus after phosphorylation of IkB.
21 results for "NFkB2" in Products
21 results for "NFkB2" in Products
NFkB2 Products
NFkB1 (NFkB p50) and NFkB2 (NFkB p52) are class I members of the Rel/NFkB family of transcription factors that also includes RelA, c-Rel and RelB. Rel/NFkB members regulate expression of genes that participate in immune, apoptotic and oncogenic processes. Class I members lack a C-terminal transcriptional activation segment found in class II members, but contain an RHD (Rel homology domain) that mediates DNA binding, nuclear localization and dimerization. NFkB1 and NFkB2 105 and 100 kDa precursors are proteolytically cleaved to 50 and 52 kDa active subunits, respectively. NFkB is predominantly localized in the cytoplasm as a complex with inhibitory IkB proteins and is released and translocated to the nucleus after phosphorylation of IkB.
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ICC/IF, KD, Simple Western |
![Western Blot: NFkB2/NFkB p100 Antibody [NBP1-87760]](https://resources.bio-techne.com/images/products/NFkB-p100-p52-Antibody-Western-Blot-NBP1-87760-img0021.jpg "Western Blot: NFkB2/NFkB p100 Antibody [NBP1-87760]")
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #291319 |
| Applications: | WB, ChIP, ICC |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #CL8266 |
| Applications: | IHC |
![Immunohistochemistry-Paraffin: NFkB2/NFkB p100 Antibody (CL8266) [NBP2-88914]](https://resources.bio-techne.com/images/products/NFkB2-NFkB-p100-Antibody-CL8266-Immunohistochemistry-Paraffin-NBP2-88914-img0007.jpg "Immunohistochemistry-Paraffin: NFkB2/NFkB p100 Antibody (CL8266) [NBP2-88914]")
Recombinant Monoclonal Antibody
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #4K3V3 |
| Applications: | IHC, WB |
![Western Blot: NFkB2/NFkB p100 Antibody (4K3V3) [NBP3-15809]](https://resources.bio-techne.com/images/products/NFkB2-NFkB-p100-Antibody-4K3V3-Western-Blot-NBP3-15809-img0002.jpg "Western Blot: NFkB2/NFkB p100 Antibody (4K3V3) [NBP3-15809]")
| Applications: | ELISA |
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, KO |
![Knockout Validated: NFkB2/NFkB p100 Antibody - Azide and BSA Free [NBP3-03135]](https://resources.bio-techne.com/images/products/NFkB2-NFkB-p100-Antibody-Knockout-Validated-NBP3-03135-img0001.jpg "Western Blot: NFkB2/NFkB p100 Antibody - Azide and BSA Free [NBP3-03135]")
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #5J6H9 |
| Applications: | WB, ELISA |
Proteasome and calpain inhibitor. Inhibits NF-κB activation
| Alternate Names: | Z-LLL-al,Z-Leu-Leu-Leu-CHO |
| Chemical Name: | N-[(Phenylmethoxy)carbonyl]-L-leucyl-N-[(1S)-1-formyl-3-methylbutyl]-L-leucinamide |
| Purity: | ≥95% (HPLC) |
Contains 4 membranes-each spotted in duplicate with 41 different proteins and 4 serine or tyrosine phosphorylation sites antibodies
Inhibits NF-κB activation
| Chemical Name: | (4β,5β,6β,22R)-5,6-Epoxy-4,22,27-trihydroxy-1-oxoergosta-2,24-dien-26-oic acid δ-lactone |
| Purity: | ≥98% (HPLC) |
Antitumor and anti-HIV agent; activates NF-κB. Also TGR5 agonist
| Chemical Name: | (+)-(3β)-3-Hydroxylup-20(29)-en-28-oic acid |
NF-κB and AP-1 dual inhibitor
| Chemical Name: | N-[3,5-Bis(trifluoromethyl)phenyl]-2-chloro-4-(trifluoromethyl)-5-pyrimidinecarboxamide |
| Purity: | ≥99% (HPLC) |
Inhibits TNF-α-induced NF-κB activation
| Chemical Name: | (9β,13α,14β,20α)-3-Hydroxy-9,13-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid |
| Purity: | ≥99% (HPLC) |
Inhibits RNAPII-mediated transcription; antitumor, anti-inflammatory and immunosuppressive
| Chemical Name: | (3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)-3b,4,4a,6,6a,7a,7b,8b,9,10-Decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)trisoxireno[4b,5:6,7:8a,9]phenanthro[1,2-c]furan-1(3H)-one |
| Purity: | ≥98% (HPLC) |
Inhibitor of NF-κB activation; also inhibits SXC and folate transporter 1
| Chemical Name: | 5-[[4-(2-Pyridylsulfamoyl)phenyl]azo]salicylic acid |
| Purity: | ≥97% (HPLC) |
Inhibitor of NF-κB activation; anti-inflammatory
| Chemical Name: | (2E)-1-(2,4-Dihydroxy-6-methoxyphenyl)-3-phenyl-2-propen-1-one |
| Purity: | ≥98% (HPLC) |
Specific inhibitor of NF-κB activation
| Alternate Names: | CAPE |
| Chemical Name: | 3-(3,4-Dihydroxyphenyl)-2-propenoic acid 2-phenylethyl ester |
| Purity: | ≥98% (HPLC) |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #CL8266 |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #CL8266 |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #CL8266 |
| Applications: | IHC |