Orexin R2/HCRTR2 Products
Hypocretin receptor 2 (HCRTR2); also known as orexin receptor 2 or OX2R is a 40 kDa 7-transmembrane G-protein-coupled glycoprotein that is a high affinity receptor for orexins A and B (hypocretins 1 and 2). In mouse brain, engagement of HCRTRs promotes wakefulness, such that absence of either orexins or their receptors creates a narcolepsy-like state. HCRTR2 also influences reward circuits involving food or addictive drugs. The extracellular portions of human HCRTR2 share 92% and 93% aa identity with corresponding portions of mouse and rat HCRTR2, respectively.
49 results for "Orexin R2/HCRTR2" in Products
49 results for "Orexin R2/HCRTR2" in Products
Orexin R2/HCRTR2 Products
Hypocretin receptor 2 (HCRTR2); also known as orexin receptor 2 or OX2R is a 40 kDa 7-transmembrane G-protein-coupled glycoprotein that is a high affinity receptor for orexins A and B (hypocretins 1 and 2). In mouse brain, engagement of HCRTRs promotes wakefulness, such that absence of either orexins or their receptors creates a narcolepsy-like state. HCRTR2 also influences reward circuits involving food or addictive drugs. The extracellular portions of human HCRTR2 share 92% and 93% aa identity with corresponding portions of mouse and rat HCRTR2, respectively.
| Applications: | WB, ELISA, MA, AP |
| Reactivity: | Human |
| Details: | Mouse IgG1 kappa Monoclonal Clone #1E3 |
| Applications: | WB, ELISA, KD |
![Western Blot: Orexin R2/HCRTR2 Antibody (1E3) [H00003062-M01]](https://resources.bio-techne.com/images/products/Orexin-R2-HCRTR2-Antibody-1E3-Western-Blot-H00003062-M01-img0006.jpg "Western Blot: Orexin R2/HCRTR2 Antibody (1E3) [H00003062-M01]")
| Reactivity: | Human |
| Details: | Mouse IgG2a Monoclonal Clone #456738 |
| Applications: | ICFlow |
| Reactivity: | Human |
| Details: | Mouse IgG2a Monoclonal Clone #456738 |
| Applications: | ICFlow |
| Reactivity: | Human |
| Details: | Mouse IgG2a Monoclonal Clone #456738 |
| Applications: | ICFlow |
| Reactivity: | Human |
| Details: | Mouse IgG2a Monoclonal Clone #456738 |
| Applications: | ICFlow |
| Reactivity: | Human |
| Details: | Mouse IgG2a Monoclonal Clone #456738 |
| Applications: | ICFlow |
| Reactivity: | Human |
| Details: | Mouse IgG2a Monoclonal Clone #456738 |
| Applications: | ICFlow |
| Reactivity: | Human |
| Details: | Mouse IgG2a Monoclonal Clone #456738 |
| Applications: | ICFlow |
| Applications: | WB |
![Western Blot: Orexin R2/HCRTR2 Overexpression Lysate [NBP2-04198]](https://resources.bio-techne.com/images/products/Orexin-Receptor-2-Overexpression-Lysate-Adult-Normal-Western-Blot-NBP2-04198-img0001.jpg "Western Blot: Orexin R2/HCRTR2 Overexpression Lysate [NBP2-04198]")
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, ELISA |
![Western Blot: Orexin R2/HCRTR2 Antibody [NB100-74579]](https://resources.bio-techne.com/images/products/Orexin-R2-HCRTR2-Antibody-Western-Blot-NB100-74579-img0003.jpg "Western Blot: Orexin R2/HCRTR2 Antibody [NB100-74579]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC |
![Immunohistochemistry-Paraffin: Orexin R2/HCRTR2 Antibody [NBP2-33718]](https://resources.bio-techne.com/images/products/Orexin-R2-HCRTR2-Antibody-Immunohistochemistry-Paraffin-NBP2-33718-img0002.jpg "Immunohistochemistry-Paraffin: Orexin R2/HCRTR2 Antibody [NBP2-33718]")
| Reactivity: | Human |
| Details: | Mouse IgG2A Monoclonal Clone #456738 |
| Applications: | Flow, CyTOF-ready |
| Reactivity: | Human |
| Details: | Mouse IgG2A Monoclonal Clone #456738 |
| Applications: | Flow, CyTOF-ready |
| Reactivity: | Human |
| Details: | Mouse IgG2A Monoclonal Clone #456738 |
| Applications: | Flow, CyTOF-ready |
| Reactivity: | Human |
| Details: | Mouse IgG2a Monoclonal Clone #456738 |
| Applications: | CyTOF-ready, ICFlow |
| Reactivity: | Human |
| Details: | Mouse IgG2b Monoclonal Clone #456723 |
| Applications: | IHC |
Potent and selective OX2 agonist
| Purity: | ≥95% (HPLC) |
Potent and selective OX2 agonist
| Chemical Name: | 3'-[[[3-[[2-[[2-(Dimethylamino)benzoyl]amino]ethyl]amino]phenyl]amino]sulfonyl]-4'-methoxy-N,N-dimethyl-[1,1'-biphenyl]-3-carboxamide dihydrochloride |
| Purity: | ≥98% (HPLC) |
Potent, dual orexin receptor antagonist
| Chemical Name: | (2S)-N-(3,5-Dimethylphenyl)-1-[(4-methoxyphenyl)sulfonyl]-2-pyrrolidinecarboxamide |
| Purity: | ≥99% (HPLC) |
Potent, dual orexin receptor antagonist
| Chemical Name: | N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide |
| Purity: | ≥98% (HPLC) |
Potent and selective OX2 antagonist
| Chemical Name: | (2S)-1-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-[(4-pyridinylmethyl)amino]-1-butanone hydrochloride |
| Purity: | ≥98% (HPLC) |
Highly potent and selective OX2 antagonist; brain penetrant
| Chemical Name: | N-Ethyl-2-[(6-methoxy-3-pyridinyl)[(2-methylphenyl)sulfonyl]amino]-N-(3-pyridinylmethyl)-acetamide |
| Purity: | ≥98% (HPLC) |
