P-Cadherin Products

Placental Cadherin, also known as Cadherin-3, is a calcium-dependent transmembrane protein in the Cadherin family. The cytoplasmic domains of Cadherins associate with the three Catenins, alpha, beta, and gamma (plakoglobin), for linking to the cytoskeleton. Cadherins play a role in development, specifically in tissue formation. They may also help to maintain tissue architecture in the adult.

P-Cadherin is constitutively expressed in the epidermis, mesothelium, corneal epithelium, and uterine decidua. Mutations in P-Cadherin are associated with hypotrichosis with juvenile macular dystrophy. P-Cadherin over-expression is observed in various malignant tumors and is often correlated with increased tumor motility and invasiveness.

Products:

• Primary Antibodies
• Proteins & Enzymes
• cDNA Clones
• ELISAs
• Proteome Profiler Antibody Arrays