SHP-2 Products
The SH2 domain-containing phosphatases, SHP-1 and SHP-2, are well-studied cytosolic tyrosine phosphatases that share many structural and regulatory features. They both have two tandem SH2 domains at the N-terminus, followed by a catalytic domain, and an inhibitory C-terminus. Despite their structural similarity, the enzymes appear to have different physiological roles and exhibit different expression patterns. SHP-1 is highly expressed in hematopoietic tissues, and in general has a negative impact on lymphocyte signaling. In contrast, SHP-2 is widely expressed, and in general promotes signaling pathways that lead to differentiation, cell growth, or migration.
56 results for "SHP-2" in Products
56 results for "SHP-2" in Products
SHP-2 Products
The SH2 domain-containing phosphatases, SHP-1 and SHP-2, are well-studied cytosolic tyrosine phosphatases that share many structural and regulatory features. They both have two tandem SH2 domains at the N-terminus, followed by a catalytic domain, and an inhibitory C-terminus. Despite their structural similarity, the enzymes appear to have different physiological roles and exhibit different expression patterns. SHP-1 is highly expressed in hematopoietic tissues, and in general has a negative impact on lymphocyte signaling. In contrast, SHP-2 is widely expressed, and in general promotes signaling pathways that lead to differentiation, cell growth, or migration.
Shp2 (PTPN11) inhibitor
| Chemical Name: | 4-[2-[1,5-Dihydro-3-(4-nitrophenyl)-5-oxo-1-phenyl-4H-pyrazol-4-ylidene]hydrazinyl]benzenesulfonic acid sodium salt |
| Purity: | ≥98% (HPLC) |
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, Simple Western, ICC |
| Source: | E. coli |
| Accession #: | NP_002825.3 |
| Applications: | EnzAct |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rat IgG2b Monoclonal Clone #255509 |
| Applications: | WB, KO |
| Reactivity: | Human, Mouse, Rat |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, KO |
| Reactivity: | Human |
| Details: | Mouse IgG1 Monoclonal Clone #6D9 |
| Applications: | IHC, WB, ELISA, ICC/IF, Flow, +1 More |
![Western Blot: SHP-2/PTPN11 Antibody (6D9)BSA Free [NBP2-37454]](https://resources.bio-techne.com/images/products/SHP-2-PTPN11-Antibody-6D9-Western-Blot-NBP2-37454-img0002.jpg "Western Blot: SHP-2/PTPN11 Antibody (6D9)BSA Free [NBP2-37454]")
| Reactivity: | Human, Mouse, Rat |
| Details: | Goat IgG |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, KO |
![Western Blot: SHP-2/PTPN11 Antibody [NBP1-33064]](https://resources.bio-techne.com/images/products/SHP-2-PTPN11-Antibody-Western-Blot-NBP1-33064-img0012.jpg "Western Blot: SHP-2/PTPN11 Antibody [NBP1-33064]")
| Reactivity: | Human, Mouse, Rat, Canine |
| Details: | Mouse IgG2A Monoclonal Clone #OTI3F2 |
| Applications: | WB, Flow |
Protein tyrosine phosphatase inhibitor
| Chemical Name: | Trisodium vanadate |
Substrate for PTP1B, TC-PTP, SHP-2, and Tyrosine Phosphatase
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ELISA, ICC/IF, IP, KO |
![Western Blot: SHP-2/PTPN11 AntibodyAzide and BSA Free [NBP3-03486]](https://resources.bio-techne.com/images/products/SHP-2-PTPN11-Antibody-Western-Blot-NBP3-03486-img0002.jpg "Western Blot: SHP-2/PTPN11 AntibodyAzide and BSA Free [NBP3-03486]")
Recombinant Monoclonal Antibody
| Reactivity: | Human, Mouse |
| Details: | Rabbit IgG Monoclonal Clone #SR2126 |
| Applications: | WB, ICC/IF, IP |
Non-competitive protein tyrosine phosphatase inhibitor
| Chemical Name: | 4-Hydroxy-3,3-dimethyl-2H-benz[g]indole-2,5(3H)-dione |
| Purity: | ≥98% (HPLC) |
| Reactivity: | Human |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, ELISA, ICC/IF, Flow |
![Western Blot: SHP-2/PTPN11 Antibody [NB100-806]](https://resources.bio-techne.com/images/products/SHP-2-PTPN11-Antibody-Western-Blot-NB100-806-img0001.jpg "Western Blot: SHP-2/PTPN11 Antibody [NB100-806]")
Recombinant Monoclonal Antibody
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #S08-3G2 |
| Applications: | IHC, WB |
![Western Blot: SHP-2/PTPN11 Antibody (S08-3G2) [NBP3-19502]](https://resources.bio-techne.com/images/products/SHP-2-PTPN11-Antibody-S08-3G2-Western-Blot-NBP3-19502-img0002.jpg "Western Blot: SHP-2/PTPN11 Antibody (S08-3G2) [NBP3-19502]")
Contains 4 membranes - each spotted in duplicate with 59 different immunoreceptor antibodies
| Reactivity: | Human |
| Details: | Mouse IgG Polyclonal |
| Applications: | WB, Func |
![Western Blot: SHP-2/PTPN11 Antibody [H00005781-B02P]](https://resources.bio-techne.com/images/products/SHP-2-PTPN11-Antibody-Western-Blot-H00005781-B02P-img0007.jpg "Western Blot: SHP-2/PTPN11 Antibody [H00005781-B02P]")
Recombinant monoclonal antibody expressed in HEK293F cells
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #6G11 |
| Applications: | IHC, WB, ELISA |
| Reactivity: | Virus |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, ELISA, ICC/IF |
![Western Blot: SHP-2/PTPN11 Antibody [NBP2-42920]](https://resources.bio-techne.com/images/products/SHP-2-PTPN11-Antibody-Western-Blot-NBP2-42920-img0002.jpg "Western Blot: SHP-2/PTPN11 Antibody [NBP2-42920]")
| Reactivity: | Human, Mouse, Rat |
| Details: | Mouse IgG1 Monoclonal Clone #M163 |
| Applications: | WB |
Recombinant monoclonal antibody expressed in HEK293F cells
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #2E2 |
| Applications: | WB, ELISA, IP |
![SHP-2/PTPN11 [p Tyr542] Antibody (2E2)](https://resources.bio-techne.com/images/products/nbp3-26397_rabbit-shp-2-ptpn11-p-tyr-542-mab-2e2-262202413221510.jpg "Immunoprecipitation: SHP-2/PTPN11 [p Tyr542] Antibody (2E2) [NBP3-26397] -")
Recombinant monoclonal antibody expressed in HEK293F cells
| Reactivity: | Human |
| Details: | Rabbit IgG Monoclonal Clone #7A1 |
| Applications: | WB, ELISA |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat, Canine |
| Details: | Mouse IgG2A Monoclonal Clone #OTI3F2 |
| Applications: | WB, Flow, CyTOF-ready |
