Sonic Hedgehog/Shh Products
Shh (Sonic Hedgehog) is expressed in embryonic tissues that are critical for the patterning of the developing central nervous system, somite, and limb. It is also involved in whisker, hair, foregut, tooth, and bone development. Shh regulates neural and hematopoietic stem cell fate and is important for thymocyte differentiation and proliferation. In adult tissue Shh is associated with cancer development and tissue remodeling following injury. Palmitoylation and cholesterol addition of Shh contribute to its membrane tethering and assembly into multimers. Lipid modification and multimerization greatly increase Shh signaling potency. Shh can be released from the plasma membrane by the cooperative action of DISP1, SCUBE2, and TACE/ADAM17. Canonical signaling of Shh is mediated by a receptor complex that includes Patched (PTCH1, PTCH2) and Smoothened (SMO).
95 results for "Sonic Hedgehog/Shh" in Products
95 results for "Sonic Hedgehog/Shh" in Products
Sonic Hedgehog/Shh Products
Shh (Sonic Hedgehog) is expressed in embryonic tissues that are critical for the patterning of the developing central nervous system, somite, and limb. It is also involved in whisker, hair, foregut, tooth, and bone development. Shh regulates neural and hematopoietic stem cell fate and is important for thymocyte differentiation and proliferation. In adult tissue Shh is associated with cancer development and tissue remodeling following injury. Palmitoylation and cholesterol addition of Shh contribute to its membrane tethering and assembly into multimers. Lipid modification and multimerization greatly increase Shh signaling potency. Shh can be released from the plasma membrane by the cooperative action of DISP1, SCUBE2, and TACE/ADAM17. Canonical signaling of Shh is mediated by a receptor complex that includes Patched (PTCH1, PTCH2) and Smoothened (SMO).
Analyzed by SEC-MALS
| Source: | E. coli |
| Accession #: | Q62226 |
| Applications: | BA |
Analyzed by SEC-MALS
| Source: | E. coli |
| Accession #: | NP_000184.1 |
| Applications: | BA |
C-terminal cholesterol, N-terminal fatty acid-modified
| Source: | HEK293 |
| Accession #: | Q15465 |
| Applications: | BA |
Intended for preclinical researchers who may transition to GMP Sonic Hedgehog/Shh (C24II) for their clinical work
| Source: | E. coli |
| Accession #: | NP_000184.1 |
| Applications: | BA |
| Source: | E. coli |
| Accession #: | Q62226 |
| Applications: | BA |
| Reactivity: | Human, Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB, IHC |
| Sensitivity: | 3.92 pg/mL |
| Applications: | ELISA |
| Assay Range: | 15.6 - 1,000 pg/mL (Cell Culture Supernates, Serum, Heparin Plasma) |
| Source: | E. coli |
| Accession #: | Q15465 |
| Applications: | BA |
Animal-Free
| Source: | E. coli |
| Accession #: | Q15465.1 |
| Applications: | BA |
| Sensitivity: | 2.37 pg/mL |
| Applications: | ELISA |
| Assay Range: | 7.81 - 500 pg/mL (Cell Culture Supernates, Serum, Heparin Plasma) |
| Reactivity: | Human, Mouse, Primate |
| Details: | Mouse IgG1 Monoclonal Clone #5H4 |
| Applications: | IHC, WB, ELISA, ICC/IF, Flow |
![Western Blot: Sonic Hedgehog/Shh Antibody (5H4) [NBP2-22126]](https://resources.bio-techne.com/images/products/Sonic-Hedgehog-Shh-Antibody-5H4-Western-Blot-NBP2-22126-img0004.jpg "Western Blot: Sonic Hedgehog/Shh Antibody (5H4) [NBP2-22126]")
| Reactivity: | Human, Mouse, Rat, Primate |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB, ICC/IF |
![Western Blot: Sonic Hedgehog/Shh AntibodyBSA Free [NBP2-22139]](https://resources.bio-techne.com/images/products/Sonic-Hedgehog-Antibody-Western-Blot-NBP2-22139-img0002.jpg "Western Blot: Sonic Hedgehog/Shh AntibodyBSA Free [NBP2-22139]")
Animal-Free
| Source: | E. coli |
| Accession #: | NP_000184.1 |
| Applications: | BA |
| Reactivity: | Mouse |
| Details: | Goat IgG Polyclonal |
| Applications: | WB |
| Reactivity: | Mouse |
| Details: | Rat IgG2a Monoclonal Clone #55626 |
| Applications: | WB |
| Reactivity: | Human, Mouse, Chicken |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB |
![Western Blot: Sonic Hedgehog/Shh Antibody [NBP1-69270]](https://resources.bio-techne.com/images/products/Sonic-Hedgehog-Shh-Antibody-Western-Blot-NBP1-69270-img0005.jpg "Western Blot: Sonic Hedgehog/Shh Antibody [NBP1-69270]")
| Assay Range: | 7.81 - 500 pg/mL |
| Applications: | ELISA |
| Applications: | AC |
| Reactivity: | Mouse |
| Details: | Rat IgG2a Monoclonal Clone #171028 |
Recombinant Monoclonal Antibody
| Reactivity: | Human, Mouse, Rat |
| Details: | Rabbit IgG Monoclonal Clone #8T4D3 |
| Applications: | WB, ICC/IF |
![Western Blot: Sonic Hedgehog/Shh Antibody (8T4D3) [NBP3-15454]](https://resources.bio-techne.com/images/products/Sonic-Hedgehog-Shh-Antibody-8T4D3-Western-Blot-NBP3-15454-img0002.jpg "Western Blot: Sonic Hedgehog/Shh Antibody (8T4D3) [NBP3-15454]")
| Applications: | ELISA |
| Applications: | ELISA |
| Applications: | WB |
![Western Blot: Sonic Hedgehog/Shh Overexpression Lysate [NBL1-15941]](https://resources.bio-techne.com/images/products/Sonic-Hedgehog-Overexpression-Lysate-Adult-Normal-Western-Blot-NBL1-15941-img0002.jpg "Western Blot: Sonic Hedgehog/Shh Overexpression Lysate [NBL1-15941]")