TBC1D1 Products
TBC1D1 is the founding member of a family of proteins sharing a 180- to 200-amino acid TBC domain and presumed to have a role in regulating cell growth and differentiation. These proteins share significant homology with TRE2/USP6, yeast Bub2, and CDC16. TBC1D1 and TBC1D4 (AS160) have been demonstrated to be Rab GAPs (GTPase-activating proteins) that link upstream to Akt and phosphoinositide 3-kinase and downstream to Rabs involved in trafficking of GLUT4 vesicles. TBC1D1 regulates insulin-mediated GLUT4 translocation through its GAP activity, and is a likely Akt substrate. Mutations in the Tbc1d1 gene lead to some cases of severe human obesity.
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39 results for "TBC1D1" in Products
39 results for "TBC1D1" in Products
TBC1D1 Products
TBC1D1 is the founding member of a family of proteins sharing a 180- to 200-amino acid TBC domain and presumed to have a role in regulating cell growth and differentiation. These proteins share significant homology with TRE2/USP6, yeast Bub2, and CDC16. TBC1D1 and TBC1D4 (AS160) have been demonstrated to be Rab GAPs (GTPase-activating proteins) that link upstream to Akt and phosphoinositide 3-kinase and downstream to Rabs involved in trafficking of GLUT4 vesicles. TBC1D1 regulates insulin-mediated GLUT4 translocation through its GAP activity, and is a likely Akt substrate. Mutations in the Tbc1d1 gene lead to some cases of severe human obesity.
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| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC, WB |
![Western Blot: TBC1D1 Antibody [NBP1-54654]](https://resources.bio-techne.com/images/products/TBC1D1-Antibody-Western-Blot-NBP1-54654-img0007.jpg "Western Blot: TBC1D1 Antibody [NBP1-54654]")
Applications: WB, ICC/IF
Reactivity:
Human
| Reactivity: | Human |
| Details: | Mouse IgG Polyclonal |
| Applications: | WB, ICC/IF |
![Western Blot: TBC1D1 Antibody [H00023216-B02P]](https://resources.bio-techne.com/images/products/TBC1D1-Antibody-Western-Blot-H00023216-B02P-img0002.jpg "Western Blot: TBC1D1 Antibody [H00023216-B02P]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC |
![TBC1D1 Antibody Immunohistochemistry-Paraffin: TBC1D1 Antibody [NBP3-21442]](https://resources.bio-techne.com/images/products/nbp3-21442_rabbit-tbc1d1-pab-852023115605.png "Immunohistochemistry-Paraffin: TBC1D1 Antibody [NBP3-21442]")
| Reactivity: | Human |
| Details: | Mouse IgG Polyclonal |
| Applications: | WB |
![Western Blot: TBC1D1 Antibody [H00023216-B01P]](https://resources.bio-techne.com/images/products/TBC1D1-Antibody-Western-Blot-H00023216-B01P-img0001.jpg "Western Blot: TBC1D1 Antibody [H00023216-B01P]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB |
![Western Blot: TBC1D1 Antibody [H00023216-D01P]](https://resources.bio-techne.com/images/products/TBC1D1-Antibody-Western-Blot-H00023216-D01P-img0001.jpg "Western Blot: TBC1D1 Antibody [H00023216-D01P]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC |
![Immunohistochemistry-Paraffin: TBC1D1 Antibody [NBP1-82928]](https://resources.bio-techne.com/images/products/TBC1D1-Antibody-Immunohistochemistry-Paraffin-NBP1-82928-img0004.jpg "Immunohistochemistry-Paraffin: TBC1D1 Antibody [NBP1-82928]")
| Applications: | WB |
![Western Blot: TBC1D1 Overexpression Lysate [NBL1-16719]](https://resources.bio-techne.com/images/products/TBC1D1-Overexpression-Lysate-Adult-Normal-Western-Blot-NBL1-16719-img0002.jpg "Western Blot: TBC1D1 Overexpression Lysate [NBL1-16719]")
| Applications: | PAGE |
![SDS-PAGE: Recombinant Human TBC1D1 His Protein [NBP2-22851]](https://resources.bio-techne.com/images/products/TBC1D1-Protein-SDS-Page-NBP2-22851-img0001.jpg "SDS-PAGE: Recombinant Human TBC1D1 His Protein [NBP2-22851]")
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | WB, IP |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IP |
| Applications: | AC |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC |
| Reactivity: | Human |
| Details: | Rabbit IgG Polyclonal |
| Applications: | IHC |