Vanilloid R-like 3/TRPV3 Products

Vanilloid Receptor-like 3 (VRL-3), also known as transient receptor potential cation channel subfamily V3 (TRPV3) is a 70 kDa member of the vanilloid receptor/TRP gene family. It is expressed on keratinocytes and neurons, and is physiologically responsive to changes in temperature between 22°C and 40°C.

Human VRL-3 is 790 amino acids (aa) in length. VRL-3 is a 6 transmembrane domain protein that contains an N- and C-terminal cytoplasmic region. Three ankyrin repeats occur in the extended N-terminal cytoplasmic region (aa # 214 - 369). There is one VRL-3 alternate splice form that shows a 6 aa substituton for the C-terminal 31 amino acids. Over amino acids 6 - 15, human VRL-3 shares 90% aa sequence identity with mouse and canine VRL-3.