Booth #1627 | May 7-11 | Baltimore Convention Center | Baltimore, MD
Cell and gene therapies offer new opportunities to treat or cure severe and rare diseases for which there are limited or no treatment options currently available, including cancers, heart disease, blood disorders, immunodeficiencies, and neurodegenerative diseases. To support scientists developing these life-changing therapies, Bio-Techne offers flexible and pioneering tools that span the cell and gene therapy research and manufacturing workflows. From non-viral gene engineering and high-quality, GMP reagents to spatial multiomics for visualizing therapeutic biodistribution, and automated analytical instrumentation, our products are designed to provide the consistency, standardization, and scalability needed to seamlessly transition research into clinical manufacturing and streamline the path to commercialization.
We look forward to speaking with you at the ASGCT 27th Annual Meeting to discuss how we can help support the development of your cell and gene therapy products.
Novel RNAscope™ Multi-omics Spatial Approach to Characterize Biodistribution and Safety of Cell and Gene Therapies
In this presentation, you will learn how you can use gold-standard RNAscope™ technology and Professional Assay Services to characterize the spatial biodistribution of gene therapy AAVs, co-detect vector and codon-optimized transgene expression, optimize capsid development, and measure preclinical safety. Easily visualize antisense oligos (ASOs), siRNAs, and corresponding target RNAs to measure biodistribution and functional changes in gene expression. Future characterize the spatial localization and activation states of engineered CAR-T cells in the tumor microenvironment in the context of established biomarkers, checkpoint markers, and cytokine and chemokine expression.
Presented by Sharel Figueredo, Ph.D.
Senior Manager, Biopharma Business Development
Bio-Techne
Date: Wednesday, May 8
Time: 4:45 PM – 5:15 PM
Room: 337-338
Protein Analytics Strategies for Gene Therapy - from Viral Vector Characterization to Clinical Trials
Date: Thursday, May 9
Time: 8:30 AM – 9:30 AM
Room: 324-326
8:30am – 8:50am: Innovative Analytical Tools for Faster Development of Cell and Gene Therapies
Presented by: Chris Heger, Ph.D.
Director, Applications Science
Bio-Techne
8:50am – 9:10am: Quantitation of Dystrophin and Microdystrophin by a Capillary-based Western Immunoassay to Support Clinical Trials for RGX-202, a Novel AAV8-based Gene Therapy for Duchenne Muscular Dystrophy
Presented by: Hiren Patel, Ph.D.
Sr. Scientist
REGENXBIO Inc.
9:10am – 9:30am: Panel Discussion on Techniques Used in R&D, Process Development, and Clinical Trials for Gene Therapies
Presented By:
Hiren Patel, Ph.D., REGENXBIO Inc.
Amira Rghei, Ph.D., Elevate Bio
Chris Heger, Ph.D., Bio-Techne
Tools & Technology Forum: Advancements in GMP and Closed System Reagents for Immune Cell Therapy Manufacturing
Presented by Miles Smith, Ph.D.
Product Manager, Genome Engineering Services
Bio-Techne
Date: Wednesday, May 8
Time: 3:45 PM - 4:00 PM
Location: Exhibit Hall
Efficient T-cell Activation and Expansion for CAR-T Therapy is Dependent on a Complex Interplay of the Starting Donor Population, Activation Antibodies, and Expansion Platform
Session Title: Cell Therapy Product Engineering, Development, and Manufacturing
Matt Heidtman, Ph.D.
Manager, Sr. Scientist
Bio-Techne
Wednesday | May 8 | 12:00 PM
Exhibit Hall | Abstract 868
Next Generation Protein Characterization of CD19-CAR Signaling Cascades
Session Title: Immune Targeting and Approaches with Genetically-Modified Cells and Cell Therapies
Charles Haitjema, Ph.D.
Senior Research Area Manager
Bio-Techne
Thursday | May 9 | 12:00 PM
Exhibit Hall | Abstract 1329
RNA/Protein Multiomics Imaging Using RNAscope™ Technologies to Understand Nonclinical Biodistribution (BD) and Persistence of Gene Therapy (GT) Products
Session Title: Molecular and Cellular Methods
Maithreyan Srinivasan, Ph.D.
Research and Development Vice President
Bio-Techne
Thursday | May 9 | 12:00 PM
Exhibit Hall | Abstract 1398
A Versatile Assay for Same-Section Spatial Visualization of Small RNA, mRNA, Exon Junction, Protein, and Protein-Protein Interactions
Session Title: Molecular and Cellular Methods
Maithreyan Srinivasan, Ph.D.
Research and Development Vice President
Bio-Techne
Thursday | May 9 | 12:00 PM
Exhibit Hall | Abstract 1397
Characterization of Adeno-Associated Virus Capsids by a Novel Capillary Isoelectric Focusing-Based Fractionation Method and Charge-Detection Mass Spectrometry
Session Title: AAV Vectors - Capsid Engineering
Chris Heger, Ph.D.
Applications Science Director
Bio-Techne
Friday | May 10 | 12:00 PM
Exhibit Hall | Abstract 1463
New Tools for Immune Cell Therapy
GMP Antibodies for Preclinical Research and Clinical Manufacturing
Advance your immune cell therapy program into clinical manufacturing with our new GMP antibodies for ex vivo use. Our Recombinant Human CD3 GMP Antibody and Human CD28 GMP Antibody are adaptable to your platform and allow you the flexibility to fine-tune your T cell activation and expansion.
Coming Soon!
Animal-Free Preclinical Proteins
R&D Systems™ Animal-free proteins are produced in dedicated animal-free laboratories and are manufactured using the same systems as our GMP-grade proteins, ensuring a seamless transition into clinical manufacturing.
Our catalog now includes Animal-free Recombinant Human BDNF and Flt-3 Ligand. Start testing! Free samples of our Animal-free proteins are available.
Skip the Reconstitution Step with Animal-Free Liquid Cytokines
Streamline your T cell culture workflow with liquid frozen IL-2, IL-7, and IL-15 cytokines. Eliminate the reconstitution step needed with lyophilized proteins, saving time, and reducing errors. Available in pre-clinical and GMP-grade formats.
ExCellerate™ Animal Component-Free Expansion Media
Achieve robust expansion and extended maintenance of your T cells, NK cells, and iPSCs. Made from completely animal-free raw materials, ExCellerate media provides a step toward defined cell culture conditions, delivering high yields with minimal variability.
Optimized Flow Cytometry Panels for CAR T Cell Phenotyping
Save time and streamline your phenotypic analysis with our optimized flow cytometry panels for T cell memory, T cell exhaustion, and T cell activation. Designed to be compatible with Bio-Techne’s Fluorokines™, fluorescent-conjugated proteins for one-step CAR detection.
Non-Viral Gene Engineering with TcBuster™
Realize the potential of gene engineering by using TcBuster to deliver your genes of interest. Integrate larger cargo sizes than viral-based methods, while maintaining high efficiency gene transfer and stable expression. Whether for proof-of-concept or manufacturing, TcBuster is an invaluable tool for engineering immune cells or iPSCs for cell therapies.
Simplify Your Cell Manufacturing by Partnering with ScaleReady™
Bringing the Future of Immune Cell Therapies to Life
GMP Small Molecules
For Stem Cell Therapy Manufacturing
Manufactured in our ISO 9001 certified facilities using strictly controlled processes, and with rigorous quality management systems, our GMP compounds are designed for use in the manufacture of cell and gene therapies.
RNA Visualization Tools
For Biodistribution, Safety Assessment, & Functional Analysis
RNAscope™ in situ hybridization (ISH) is the most preferred and trusted technology for leading pharmaceutical and biotech companies for evaluation of therapeutic biodistribution and cellular tropism. Quantify changes in gene expression and cellular function confidently, to optimize therapeutic efficacy and safety.
Instruments to Support Cell and Gene Therapy Workflows
One Maurice™ System for Analyzing Multiple CQAs
Whether you’re analyzing AAVs, lentiviruses, or GMP proteins, get the information you need on identity, purity, charge, and stability using the Maurice system.
One instrument enables
- Identity of different AAV serotypes
- Assessment of empty/full capsids
- Determination of lentiviral titer
- Qualification of GMP cytokines
Simple Western™ Automated Western Blot Systems
Jess™ provides high specificity detection in cell or tissue lysates, enabling quantitative and reproducible characterization of cell and gene therapy products across development and manufacturing.
Simple Cell Sorting and Single Cell Dispensing with Pala
Gentle cell sorting and single cell dispensing for any lab. Isolate cells in tubes, 96 well or 384 well plates with high viability and minimal sample dead volume. The Pala comes equipped with 2 lasers to offer a breadth of fluorescent markers to isolate cells of interest.
Compact ELISA Plate Reader
Personalize your lab space with Bio-Techne’s compact and affordable ELISA plate reader, Simple Reader™. Designed with precision and versatility at its core, this compact ELISA plate reader is a must-have for any laboratory seeking to enhance research capabilities and optimize available space.
High Throughput 72x2 Multiplexing Cartridge for Ella™
Boost your productivity with the new 72-sample, 2-plex cartridge on Ella, a next-generation benchtop automated ELISA platform. Choose from a menu of the most common 50+ human cytokines/chemokines to design your 2-plex assay at half the cost of traditional manual immunoassays.
Application Notes and Whitepapers
- G-Rex® Fill-and-Forget Workflow: Robust T Cell Expansion with Bio-Techne GMP Reagents in G-Rex Bioreactors
- Accelerating Cell Therapy Discovery & Development with Non-Viral Gene Engineering
- Characterize Your Viral Vectors from Discovery to GMP Release with Maurice™
- Reliable Quantification of Cell Potency: Simple Plex Assays in Common Cell Media
- Lentiviral Vector Analysis for Cell and Gene Therapy Made Simple
- Unraveling the Signaling Web in Stem Cells for Regenerative Medicine with Simple Western™
- A Simple Flow Cytometry-Based Assay for Detecting Chimeric Antigen Receptor (CAR) Expression Using Fluorokines™
eBooks
- The Role of Analytics in Cell and Gene Therapy Reproducibility and Regulatory Approval
- T Cell-Based Therapies eBook