Designed to Simplify Your Cell Therapy
ProPak GMP cytokines and bagged GMP T cell media were created to help reduce variability and risk in your T cell therapy. GMP IL-2, IL-7, IL-15, and Human T Cell Media are now available in single-use bags, designed to integrate seamlessly into your closed process workflow.
View all available ready-to-use protein formats and see how optimal cytokine dosing was determined with data from a cytokine titration study.
View all Ready-to-Use Cytokines
Available Closed Process Reagents | |||
| GMP IL-2 | GMP IL-7 | GMP IL-15 | GMP T Cell Media |
Benefits of Closed Process Solutions
Closed System Process
To minimize risk, ProPak GMP cytokines and GMP T cell media bags are designed to integrate seamlessly into a closed system process, mitigating the risk of contamination.
Weldable Tubing
Each bag is outfitted with weldable tubing, so you can connect a ProPak directly to your media bag. Industry standard PVC tubing creates a fully closed cytokine addition step that can then be added to a 1 L bioreactor, such as the G-Rex.
Optimized Performance
After extensive investigation, our scientists identified 10 µg as the optimal dose of IL-2, IL-7, and IL-15 in a 1 L cell culture process. Each single-use ProPak supplies the perfect amount of protein, removing an unwanted source of variability in your process.
Reduced Manual Touchpoints
Removal of reconstitution and aliquot steps leads to less hands-on technician time. This reduces risks of error while streamlining your journey to the clinic.
Ready-to-Use Format
ProPak GMP cytokines can be stored at -20 °C for long term storage* or at 2-8 °C for up to 4 weeks.
*Accelerated stability testing currently underway to support a 2 year shelf-life at -20 °C.
GMP Human T Cell Media can be stored at 2-8 °C and protected from light, up to the use by date on the Certificate of Analysis.
A Partnership to Bring You Closed Process Solutions
ProPak GMP cytokines and GMP T cell media bags have been optimized for a 1 L G-Rex bioreactor process (or similar) and will also be available through our partnership with ScaleReady.
T Cell Expansion with ProPak Cytokines
ProPak Cytokines Support Robust T Cell Growth
ProPak, liquid, or lyophilized IL-7 and IL-15 were added to Xeno-free GMP Human T Cell Media (Catalog # CCM038-GMP) with 5% huAB Serum. T cells from 3 donors were activated and expanded in G-Rex bioreactors for 9 days and assessed for fold expansion and cell viability. Data is the average of 4 independent experiments with 3 donors per experiment, error bars ± SD.