5-HT6 Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NLS652

Novus Biologicals, part of Bio-Techne
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NLS652
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Key Product Details

Species Reactivity

Validated:

Human, Rat, Canine, Equine, Hamster, Monkey, Primate

Predicted:

Bat (94%), Bovine (94%), Chimpanzee (100%), Mouse (94%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

0.7 mg/ml

View all 5-HT6 Antibodies »

Product Specifications

Immunogen

Synthetic 17 amino acid peptide from C-terminus of human 5-HT6.

Epitope

C-Terminus

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (100%), Marmoset (100%), Turkey (82%), Chicken (82%), Xenopus (82%), Zebrafish (82%).

Localization

Multi pass membrane protein.

Specificity

Human 5-HT6. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

Product can be stored undiluted at 4C for up to 1 month.

Scientific Data Images for 5-HT6 Antibody - BSA Free

Immunohistochemistry-Paraffin: 5-HT6 Antibody - BSA Free [NLS652]

Immunohistochemistry-Paraffin: 5-HT6 Antibody - BSA Free [NLS652]

Immunohistochemistry-Paraffin: 5-HT6 Antibody [NLS652] - Analysis of anti-5HT6 antibody with human brain, cerebellum.
5-HT6 Antibody - BSA Free

Immunohistochemistry-Paraffin: 5-HT6 Antibody - BSA Free [NLS652] -

Immunohistochemistry-Paraffin: 5-HT6 Antibody - BSA Free [NLS652] - Immunohistochemistry of formalin-fixed, paraffin-embedded Human, Brain, Cerebellum tissue

Applications for 5-HT6 Antibody - BSA Free

Application
Recommended Usage

Immunohistochemistry-Paraffin

10 - 20 ug/ml
Application Notes
.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.1% Sodium Azide

Concentration

0.7 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

Background: 5-HT6

5-HT6, a Serotonin Receptor, appears to regulate cholinergic neurotransmission in the brain rather than the expected interaction as a modulator of dopaminergic transmission. This interaction predicts a possible role for 5-HT6 Receptor antagonists in the treatment of learning and memory disorders. The 5-HT6 Receptor is abundant in limbic areas, which participate in the control of mood and emotion. Some antidepressants and antipsychotics are potent 5-HT6 Receptor antagonists, making this gene valuable for the pharmaceutical industry. 5-HT6 may be involved in the pathogenesis of mood disorders, schizophrenia, in Alzheimer's disease. A splice variant that has a 289bp deletion in the transmembrane region IV and the third intracellular loop has been isolated. 5-HT6 Receptor has been reported primarily in striatum of the brain. Expression has also been seen in stomach, spinal cord, and the lymphoid tissues of rats, including peripheral blood lymphocytes, spleen, and thymus. ESTs have been isolated from brain libraries.

Long Name

5-Hydroxytryptamine Receptor 6

Alternate Names

HTR6

Entrez Gene IDs

3362 (Human)

Gene Symbol

HTR6

UniProt

P50406 (Human)

Additional 5-HT6 Products

Product Documents for 5-HT6 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for 5-HT6 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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