ABCA7 Antibody (7A1-144) [PE]

Novus Biologicals, part of Bio-Techne | Catalog # NB400-163PE

Novus Biologicals, part of Bio-Techne
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NB400-163PE
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Key Product Details

Species Reactivity

Mouse

Applications

Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

PE (Excitation = 488 nm, Emission = 575 nm)

Antibody Source

Monoclonal Rat IgG2a Kappa Clone # 7A1-144

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all ABCA7 Antibodies »

Product Specifications

Immunogen

Mouse ABCA7 stably-transfected HeLa cells. [UniProt# Q91V24]

Localization

Cell Membrane and Cytoplasmic

Clonality

Monoclonal

Host

Rat

Isotype

IgG2a Kappa

Applications for ABCA7 Antibody (7A1-144) [PE]

Application
Recommended Usage

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS

Preservative

0.05% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark.

Background: ABCA7

ABCA7 (ATP-binding cassette sub-family A member 7) belongs to "A" subfamily of ABC transporters that predominantly transport lipids and other lipophilic molecules across membranes. ABCA7 shows higher expression in brain, lung, adrenal gland and spleen as well as hematopoietic tissues. It localizes to cell membrane ruffles/phagocytic cups of activated macrophages; to cytoplasm (Golgi and endosomes) of resting macrophages, and to the apical brush border of cells in the proximal tubules of kidney. It is also detected in both the plasma membrane and in intracellular compartments in myelo-lymphatic tissues (peripheral leukocytes, thymus, spleen, and bone marrow). ABCA7 facilitates the transport of phospholipids and, to a lesser extent, cholesterol, across cell membranes to extracellular apoAI and apoE discoidal lipoprotein complexes. Moreover, it implicates in macrophages mediated phagocytosis of apoptotic cells, and binds APOA1 for involving in apolipoprotein-mediated phospholipid efflux from cells. ABCA7 also mediate cholesterol efflux, and can regulate the cellular ceramide homeostasis during keratinocytes differentiation.

Alternate Names

ABCA-SSN, ABCXATP-binding cassette sub-family A member 7, ATP-binding cassette, sub-family A (ABC1), member 7, Autoantigen SS-N, EC 2.2.1.1, EC 3.6.3, EC 3.6.3.41, FLJ40025, Macrophage ABC transporter

Gene Symbol

ABCA7

Additional ABCA7 Products

Product Documents for ABCA7 Antibody (7A1-144) [PE]

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for ABCA7 Antibody (7A1-144) [PE]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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