ABCB11 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-89319

Novus Biologicals, part of Bio-Techne
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NBP1-89319
NBP1-89319-25ul
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Validated:

Human

Cited:

Human

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin

Cited:

IF/IHC

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all ABCB11 Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: RLSTVRAADTIIGFEHGTAVERGTHEELLERKGVYFTLVTLQSQGNQALNEEDIKDATEDDMLARTFSRGSYQDSLRASIRQRSKSQLSYLVHEPPLAVVDHKSTYEEDRKDKDIPVQEEVEPAPVRRILK

Reactivity Notes

Reactivity reported in scientific literature (PMID: 24614073)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for ABCB11 Antibody

Immunohistochemistry-Paraffin: ABCB11 Antibody [NBP1-89319]

Immunohistochemistry-Paraffin: ABCB11 Antibody [NBP1-89319]

Immunohistochemistry-Paraffin: ABCB11 Antibody [NBP1-89319] - Staining in human liver and skeletal muscle tissues . Corresponding ABCB11 RNA-seq data are presented for the same tissues.
Immunohistochemistry: ABCB11 Antibody [NBP1-89319]

Immunohistochemistry: ABCB11 Antibody [NBP1-89319]

Immunohistochemistry: ABCB11 Antibody [NBP1-89319] - Histopathology of ABCB11 disease. (a) Giant-cell hepatitis (arrows) with hepatocanalicular cholestasis and (b) complete absence of ABCB11/BSEP protein are typical findings in PFIC2 patients. Inset: immunohistochemical positivity of BSEP in the apical (canalicular) domain of hepatocytes in a healthy control. (a) Hematoxylin and eosin, original magnification x200. (b, inset) Immunohistochemical staining with ABCB11 Rabbit Polyclonal Antibody (NBP1-89319, Novus Biologicals, USA), original magnification x200 (b), x400 (inset). Image collected and cropped by CiteAb from the following publication (https://pubmed.ncbi.nlm.nih.gov/30148122) licensed under a CC-BY license.
Immunohistochemistry-Paraffin: ABCB11 Antibody [NBP1-89319]

Immunohistochemistry-Paraffin: ABCB11 Antibody [NBP1-89319]

Immunohistochemistry-Paraffin: ABCB11 Antibody [NBP1-89319] - Staining of human liver shows moderate to strong membranous positivity in bile canaliculi.
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Applications for ABCB11 Antibody

Application
Recommended Usage

Immunohistochemistry

1:2500 - 1:5000

Immunohistochemistry-Paraffin

1:2500 - 1:5000
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: ABCB11

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy. (provided by RefSeq)

Alternate Names

ABC member 16, MDR/TAP subfamily, ABC16, ATP-binding cassette sub-family B member 11, ATP-binding cassette, sub-family B (MDR/TAP), member 11, bile salt export pump, BSEP, BSEPPFIC2, EC 3.6.3, EC 3.6.3.44, PFIC-2, PGY4, progressive familial intrahepatic cholestasis 2, sister p-glycoprotein, SPGPBRIC2

Entrez Gene IDs

8647 (Human)

Gene Symbol

ABCB11

UniProt

O95342 (Human)

Additional ABCB11 Products

Product Documents for ABCB11 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for ABCB11 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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