Abraxas Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-76827

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Validated:

Human, Mouse

Predicted:

Bovine (93%), Rat (100%). Backed by our 100% Guarantee.

Applications

ELISA, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

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Product Specifications

Immunogen

Antibody was raised against a 15 amino acid synthetic peptide from near the amino terminus of human CCDC98. The immunogen is located within amino acids 80 - 130 of CCDC98. Amino Acid Squence: WYKFRRHSDQIMTFR

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Chicken (87%)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Abraxas Antibody - BSA Free

Western Blot: Abraxas AntibodyBSA Free [NBP1-76827]

Western Blot: Abraxas AntibodyBSA Free [NBP1-76827]

Western Blot: Abraxas Antibody [NBP1-76827] - Abraxas Antibody Human breast tissue lysate in (A) the absence and (B) presence of blocking peptide with CCDC98 antibody at 1 ug/ml.
Immunohistochemistry-Paraffin: Abraxas Antibody - BSA Free [NBP1-76827]

Immunohistochemistry-Paraffin: Abraxas Antibody - BSA Free [NBP1-76827]

Immunohistochemistry-Paraffin: Abraxas Antibody [NBP1-76827] - Abraxas Antibody Human breast tissue with FAM175A antibody at 5 ug/ml.

Applications for Abraxas Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunohistochemistry

5 ug/ml

Immunohistochemistry-Paraffin

5 ug/ml

Western Blot

1 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Abraxas

CCDC98, also known as Abraxas 1, was identified through protein binding studies using the breast and ovarian predisposition protein BRCA1 as the binding target. CCDC98 recruits RAP80, a ubiquitin-binding protein, to BRCA1, allowing the formation of BRCA1 foci in response to DNA damage caused by ionizing radiation. Both CCDC98 and RAP80 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair. Cells depleted of either CCDC98 or RAP80 exhibited increased sensitivity to ionizing radiation, although not as much as in BRCA1-depleted cells, suggesting that CCDC98 and RAP80 control only part of the DNA damage response role of BRCA1. At least two isoforms of CCDC98 are known to exist.

Alternate Names

ABRA1, BRCA1-A complex subunit Abraxas, CCDC98, family with sequence similarity 175, member A

Gene Symbol

ABRAXAS1

UniProt

NP_620775 (Human)

Additional Abraxas Products

Product Documents for Abraxas Antibody - BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Abraxas Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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