Activin RIA/ALK-2/Activin Receptor Type 1 Antibody (2D5)

Novus Biologicals, part of Bio-Techne | Catalog # H00000090-M07

Novus Biologicals, part of Bio-Techne
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H00000090-M07
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Key Product Details

Species Reactivity

Human

Applications

ELISA, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 kappa Clone # 2D5

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Activin RIA/ALK-2 Antibodies »

Product Specifications

Immunogen

ACVR1 (AAH33867, 21 a.a. ~ 120 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. MEDEKPKVNPKLYMCVCEGLSCGNEDHCEGQQCFSSLSINDGFHVYQKGCFQVYEQGKMTCKTPPSPGQAVECCQGDWCNRNITAQLPTKGKSFPGTQNF

Specificity

Reacts with activin A receptor, type I.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1 kappa

Description

Quality control test: Antibody Reactive Against Recombinant Protein.

Scientific Data Images for Activin RIA/ALK-2/Activin Receptor Type 1 Antibody (2D5)

Western Blot: Activin RIA/ALK-2/Activin Receptor Type 1 Antibody (2D5) [H00000090-M07]

Western Blot: Activin RIA/ALK-2/Activin Receptor Type 1 Antibody (2D5) [H00000090-M07]

Western Blot: Activin RIA/ALK-2/Activin Receptor Type 1 Antibody (2D5) [H00000090-M07] - Analysis of ACVR1 expression in transfected 293T cell line by ACVR1 monoclonal antibody (M07), clone 2D5. Lane 1: ACVR1 transfected lysate (Predicted MW: 57.2 KDa). Lane 2: Non-transfected lysate.
ELISA: Activin RIA/ALK-2/Activin Receptor Type 1 Antibody (2D5) [H00000090-M07]

ELISA: Activin RIA/ALK-2/Activin Receptor Type 1 Antibody (2D5) [H00000090-M07]

ELISA: Activin RIA/ALK-2/Activin Receptor Type 1 Antibody (2D5) [H00000090-M07] - Detection limit for recombinant GST tagged ACVR1 is 0.03 ng/ml as a capture antibody.

Applications for Activin RIA/ALK-2/Activin Receptor Type 1 Antibody (2D5)

Application
Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
This antibody is reactive against recombinant protein in WB and ELISA.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

In 1x PBS, pH 7.4

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: Activin RIA/ALK-2

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq]

Long Name

Activin Receptor IA

Alternate Names

ActivinRIA, ACVR1, ALK-2, ALK2

Entrez Gene IDs

90 (Human)

Gene Symbol

ACVR1

UniProt

AAH33867 (Human)

Additional Activin RIA/ALK-2 Products

Product Documents for Activin RIA/ALK-2/Activin Receptor Type 1 Antibody (2D5)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Activin RIA/ALK-2/Activin Receptor Type 1 Antibody (2D5)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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