Activin RIA/ALK-2/Activin Receptor Type 1 Antibody (2E2C11) - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-61799

Novus Biologicals, part of Bio-Techne
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NBP2-61799
NBP2-61799-0.025ml
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Key Product Details

Species Reactivity

Validated:

Human

Applications

ELISA, Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # 2E2C11

Format

BSA Free

Concentration

1 mg/ml

View all Activin RIA/ALK-2 Antibodies »

Product Summary

Immunogen

Purified recombinant fragment of human Activin RIA/ALK-2/Activin Receptor Type 1 (AA: 21-120) expressed in E. Coli.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Theoretical MW

57.2 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images

Western Blot: Activin RIA/ALK-2/Activin Receptor Type 1 Antibody (2E2C11)BSA Free [NBP2-61799]

Western Blot: Activin RIA/ALK-2/Activin Receptor Type 1 Antibody (2E2C11)BSA Free [NBP2-61799]

Western Blot: Activin RIA/ALK-2/Activin Receptor Type 1 Antibody (2E2C11) [NBP2-61799] - Analysis using ACVR1 mAb against human ACVR1 (AA: 21-120) recombinant protein. (Expected MW is 37.1 kDa)
Immunocytochemistry/ Immunofluorescence: Activin RIA/ALK-2/Activin Receptor Type 1 Antibody (2E2C11) - BSA Free [NBP2-61799]

Immunocytochemistry/ Immunofluorescence: Activin RIA/ALK-2/Activin Receptor Type 1 Antibody (2E2C11) - BSA Free [NBP2-61799]

Immunocytochemistry/Immunofluorescence: Activin RIA/ALK-2/Activin Receptor Type 1 Antibody (2E2C11) [NBP2-61799] - Analysis of Hela cells using ACVR1 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Goat anti-Mouse IgG (H+L) DyLight 488 Secondary antibody was used.
Immunohistochemistry-Paraffin: Activin RIA/ALK-2/Activin Receptor Type 1 Antibody (2E2C11) - BSA Free [NBP2-61799]

Immunohistochemistry-Paraffin: Activin RIA/ALK-2/Activin Receptor Type 1 Antibody (2E2C11) - BSA Free [NBP2-61799]

Immunohistochemistry-Paraffin: Activin RIA/ALK-2/Activin Receptor Type 1 Antibody (2E2C11) [NBP2-61799] - Analysis of endometrial cancer tissues using ACVR1 mouse mAb with DAB staining.
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Applications

Application
Recommended Usage

ELISA

1:10000

Flow Cytometry

1:200-1:400

Immunocytochemistry/ Immunofluorescence

1:10-1:500

Immunohistochemistry

1:200-1:1000

Immunohistochemistry-Paraffin

1:200-1:1000

Western Blot

1:500-1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS

Format

BSA Free

Preservative

0.05% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Activin RIA/ALK-2

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive.

Long Name

Activin Receptor IA

Alternate Names

ActivinRIA, ACVR1, ALK-2, ALK2

Gene Symbol

ACVR1

Additional Activin RIA/ALK-2 Products

Product Documents

Product Datasheets

Certificate of Analysis

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Product Specific Notices

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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