Activin RIA/ALK-2/Activin Receptor Type 1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-56432

Novus Biologicals, part of Bio-Techne
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NB100-56432
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Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.5 mg/ml

View all Activin RIA/ALK-2 Antibodies »

Product Specifications

Immunogen

A synthetic peptide corresponding to amino acids 475-525 of human ACVR1 was used as immunogen.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Activin RIA/ALK-2/Activin Receptor Type 1 Antibody

Western Blot: Activin RIA/ALK-2/Activin Receptor Type 1 Antibody [NB100-56432]

Western Blot: Activin RIA/ALK-2/Activin Receptor Type 1 Antibody [NB100-56432]

Western Blot: Activin RIA/ALK-2/Activin Receptor Type 1 Antibody [NB100-56432] - Analysis of Activin RIA/ALK-2/Activin Receptor Type 1 in mouse kidney lysate using this antibody at 5 ug/ml

Applications for Activin RIA/ALK-2/Activin Receptor Type 1 Antibody

Application
Recommended Usage

Western Blot

3-5 ug/ml
Application Notes
In human kidney, additional bands are seen at approximately 27 and 14 kD.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS containing 0.2% gelatin.

Preservative

0.05% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Activin RIA/ALK-2

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive.

Long Name

Activin Receptor IA

Alternate Names

ActivinRIA, ACVR1, ALK-2, ALK2

Entrez Gene IDs

90 (Human); 11477 (Mouse); 79558 (Rat)

Gene Symbol

ACVR1

UniProt

NP_001104537.1 (Human)

Additional Activin RIA/ALK-2 Products

Product Documents for Activin RIA/ALK-2/Activin Receptor Type 1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Activin RIA/ALK-2/Activin Receptor Type 1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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