Activin RIA/ALK-2/Activin Receptor Type 1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-33096

Novus Biologicals, part of Bio-Techne
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NBP1-33096
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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Predicted:

Bovine (100%), Rat (99%), Rhesus Macaque (100%), Xenopus (93%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Activin RIA/ALK-2 Antibodies »

Product Summary for Activin RIA/ALK-2/Activin Receptor Type 1 Antibody

Immunogen

Recombinant protein encompassing a sequence within the center region of human Activin RIA/ALK-2/Activin Receptor Type 1. The exact sequence is proprietary.

Reactivity Notes

Xenopus laevis (93%). Canine reactivity reported by customer review.

Localization

Membrane

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

57 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Activin RIA/ALK-2/Activin Receptor Type 1 Antibody

Immunohistochemistry-Paraffin: Activin RIA/ALK-2/Activin Receptor Type 1 Antibody [NBP1-33096]

Immunohistochemistry-Paraffin: Activin RIA/ALK-2/Activin Receptor Type 1 Antibody [NBP1-33096]

Immunohistochemistry-Paraffin: Activin RIA/ALK-2/Activin Receptor Type 1 Antibody [NBP1-33096] - Cal27 xenograft. Activin A Receptor type I antibody dilution: 1:500. Antigen Retrieval: Trilogy™ (EDTA based, pH 8.0) buffer, 15min.
Immunohistochemistry-Paraffin: Activin RIA/ALK-2/Activin Receptor Type 1 Antibody [NBP1-33096]

Immunohistochemistry-Paraffin: Activin RIA/ALK-2/Activin Receptor Type 1 Antibody [NBP1-33096]

Immunohistochemistry-Paraffin: Activin RIA/ALK-2/Activin Receptor Type 1 Antibody [NBP1-33096] - Mouse prostate. Activin A Receptor type I antibody dilution: 1:500. Scale bar = M um.Antigen Retrieval: Trilogy™ (EDTA based, pH 8.0) buffer, 15min.

Applications for Activin RIA/ALK-2/Activin Receptor Type 1 Antibody

Application
Recommended Usage

Immunohistochemistry-Paraffin

1:100-1:1000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Reviewed Applications

Read 1 review rated 3 using NBP1-33096 in the following applications:

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

0.1M Tris (pH 7), 0.1M Glycine, 10% Glycerol

Preservative

0.01% Thimerosal

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: Activin RIA/ALK-2

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive.

Long Name

Activin Receptor IA

Alternate Names

ActivinRIA, ACVR1, ALK-2, ALK2

Gene Symbol

ACVR1

Additional Activin RIA/ALK-2 Products

Product Documents for Activin RIA/ALK-2/Activin Receptor Type 1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Activin RIA/ALK-2/Activin Receptor Type 1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause reproductive toxicity with developmental effects.  For more information go to www.P65Warnings.ca.gov.

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