Activin RIIB Antibody (bimagrumab)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-28282

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-28282-100ug
NBP3-28282-50ug
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Key Product Details

Species Reactivity

Human

Applications

ELISA, Flow Cytometry, Functional

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Human IgG1 Clone # bimagrumab

Concentration

LYOPH mg/ml

View all Activin RIIB Antibodies »

Product Specifications

Immunogen

ACVR2B

Reactivity Notes

Predicted species reactivity: Mouse, Rat, Cynomolgus

Clonality

Monoclonal

Host

Human

Isotype

IgG1

Endotoxin Level

< 0.001EU/ug,determined by LAL method.

Description

Expressed from CHO. The heavy chain type is huIgG1, and the light chain type is hulambda. It has a predicted MW of 145.5 kDa.

Also known as 'bimagrumab'.

Upon receipt, store immediately at -20C or lower for 24 months in a lyophilized state. - 80C for 3 months after reconstitution. Avoid repeated freeze-thaw cycles.

Scientific Data Images for Activin RIIB Antibody (bimagrumab)

Activin RIIB Antibody (bimagrumab)

ELISA: Activin RIIB Antibody (bimagrumab)[NBP3-28282] -

Immobilized human ACVR2B chis at 2 ug/mL can bind Activin RIIB Antibody (bimagrumab), EC50=0.005171 ug/mL.

Applications for Activin RIIB Antibody (bimagrumab)

Application
Recommended Usage

ELISA

Optimal dilutions of this antibody should be experimentally determined.

Flow Cytometry

Optimal dilutions of this antibody should be experimentally determined.

Functional

Optimal dilutions of this antibody should be experimentally determined.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Reconstitution

Reconstitute with sterile, distilled water to a final concentration of 1 mg/ml. Gently shake to solubilize completely. Do not vortex.

Formulation

Lyophilized from 25mM histidine, 8% sucrose, 0.01% Tween80 (pH6.2)

Preservative

No Preservative

Concentration

LYOPH mg/ml

Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: Activin RIIB

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq]

Long Name

Activin Receptor IIB

Alternate Names

ActivinRIIB, ACVR2B

Gene Symbol

ACVR2B

UniProt

Q13705

Additional Activin RIIB Products

Product Documents for Activin RIIB Antibody (bimagrumab)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Activin RIIB Antibody (bimagrumab)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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