Activin RIIB Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-15268

Novus Biologicals, part of Bio-Techne
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NBP2-15268
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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Predicted:

Bovine (97%), Porcine (100%), Rat (99%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Activin RIIB Antibodies »

Product Summary for Activin RIIB Antibody

Immunogen

Recombinant protein encompassing a sequence within the center region of human Activin RIIB. The exact sequence is proprietary.

Reactivity Notes

Chicken (89%).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

58 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Activin RIIB Antibody

Western Blot: Activin RIIB Antibody [NBP2-15268]

Western Blot: Activin RIIB Antibody [NBP2-15268]

Western Blot: Activin RIIB Antibody [NBP2-15268] - Various whole cell extracts (30 ug) were separated by 10% SDS-PAGE, and the membrane was blotted with Activin Receptor Type IIB antibody [N1C1] diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody was used to detect the primary antibody.
Immunohistochemistry-Paraffin: Activin RIIB Antibody [NBP2-15268]

Immunohistochemistry-Paraffin: Activin RIIB Antibody [NBP2-15268]

Immunohistochemistry-Paraffin: Activin RIIB Antibody [NBP2-15268] - Activin Receptor Type IIB antibody [N1C1] detects Activin Receptor Type IIB protein at cytoplasm by immunohistochemical analysis. Sample: Paraffin-embedded mouse placenta. Activin Receptor Type IIB stained by Activin Receptor Type IIB antibody [N1C1] diluted at 1:500. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min
Western Blot: Activin RIIB Antibody [NBP2-15268]

Western Blot: Activin RIIB Antibody [NBP2-15268]

Western Blot: Activin RIIB Antibody [NBP2-15268] - Activin RIIB Type 2B Antibody Sample (30 ug of whole cell lysate) A: U87-MG 7.5% SDS PAGE; antibody diluted at 1:1000.
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Applications for Activin RIIB Antibody

Application
Recommended Usage

Immunohistochemistry-Paraffin

1:100-1:1000

Western Blot

1:500-1:50000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

PBS (pH 7), 20% Glycerol, 1% BSA

Preservative

0.025% Proclin 300

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: Activin RIIB

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq]

Long Name

Activin Receptor IIB

Alternate Names

ActivinRIIB, ACVR2B

Gene Symbol

ACVR2B

UniProt

Q13705

Additional Activin RIIB Products

Product Documents for Activin RIIB Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for Activin RIIB Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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