ADAM10 Antibody (11G2) - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-21496

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Human, Mouse (Negative)

Applications

Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Frozen, Immunohistochemistry-Paraffin, Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 kappa Clone # 11G2

Format

BSA Free

Concentration

1 mg/ml

View all ADAM10 Antibodies »

Product Specifications

Immunogen

Jurkat cells

Epitope

The mouse monoclonal antibody 11G2 recognizes an extracellular/luminal epitope of ADAM10.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1 kappa

Scientific Data Images for ADAM10 Antibody (11G2) - BSA Free

Flow Cytometry: ADAM10 Antibody (11G2) - BSA Free [NBP3-21496] -

Flow cytometry surface staining pattern of human peripheral whole blood stained using anti-human ADAM10 (11G2) purified antibody (concentration in sample 1.67 ug/ml, GAM APC).

Flow Cytometry: ADAM10 Antibody (11G2) - BSA Free [NBP3-21496] -

Separation of human monocytes stained using anti-human ADAM10 (11G2) purified antibody (concentration in sample 1.67 ug/ml, GAM APC) from human monocytes unstained by primary antibody (GAM APC, black-dashed) in flow cytometry analysis (surface staining).

Applications for ADAM10 Antibody (11G2) - BSA Free

Application
Recommended Usage

Flow Cytometry

1-5 ug/ml

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS, pH 7.4

Format

BSA Free

Preservative

0.9% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: ADAM10

Proinflammatory cytokine tumor necrosis factor-alpha (TNF-a) contributes to a variety of inflammatory responses and programmed cell death. Notch receptor and its ligand participate in cell fate decisions during vertebrate development and are associated with several human disorders, including a T-cell lymphoma. TNF-a, notch and its ligand delta are all membrane-bond molecules, which are cleaved by proteases to release mature proteins or functional receptor. ADAM10, a metalloprotease-disintegrin in the family of mammalian ADAM (for a disintegrin and metalloprotease), was recently identified to cleave TNF-a, notch and its ligand delta (1-3). The genes encoding human, mouse, and bovine ADAM10 were recently cloned and designated ADAM 10, kuzbanian (KUZ), and MADM, respectively, (1,2,4). ADAM10 mRNA is expressed in a variety of human and bovine tissues (1,4).

Long Name

A Disintegrin and Metalloprotease-like Domain 10

Alternate Names

CD156c, Kuzbanian, MADM

Gene Symbol

ADAM10

Additional ADAM10 Products

Product Documents for ADAM10 Antibody (11G2) - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for ADAM10 Antibody (11G2) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Privacy and Cookie Policy
Site Map
© Copyright 2024 Bio-Techne. All Rights Reserved.