ADAMTS4 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-54369

Novus Biologicals, part of Bio-Techne
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NBP1-54369
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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Cited:

Mouse

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.5 mg/ml

View all ADAMTS4 Antibodies »

Product Specifications

Immunogen

Synthetic peptides corresponding to ADAMTS4(ADAM metallopeptidase with thrombospondin type 1 motif, 4) The peptide sequence was selected from the N terminal of ADAMTS4 (AAH30812). Peptide sequence GVQVEGLTVQYLGQAPELLGGAEPGTYLTGTINGDPESVASLHWDGGALL. The peptide sequence for this immunogen was taken from within the described region.

Reactivity Notes

Mouse reactivity reported in scientific literature (PMID:31830525).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

37 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Description

The addition of 50% glycerol is optional for those storing this antibody at -20C and not aliquoting smaller units. However, please note that glycerol may interrupt some downstream antibody applications and should be added with caution.

Scientific Data Images for ADAMTS4 Antibody

Western Blot: ADAMTS4 Antibody [NBP1-54369]

Western Blot: ADAMTS4 Antibody [NBP1-54369]

Western Blot: ADAMTS4 Antibody [NBP1-54369] - Sample Tissue: Human Fetal Lung Antibody Dilution: 1.0 ug/ml
Immunohistochemistry-Paraffin: ADAMTS4 Antibody [NBP1-54369]

Immunohistochemistry-Paraffin: ADAMTS4 Antibody [NBP1-54369]

Immunohistochemistry-Paraffin: ADAMTS4 Antibody [NBP1-54369] - Human kidney Tissue, antibody concentration 4-8ug/ml. Cells with positive label: renal corpuscle cells (indicated with arrows) 400X magnification.
Western Blot: ADAMTS4 Antibody [NBP1-54369]

Western Blot: ADAMTS4 Antibody [NBP1-54369]

Western Blot: ADAMTS4 Antibody [NBP1-54369] - HepG2 cell lysate, Antibody Titration: 0.2-1 ug/ml

Applications for ADAMTS4 Antibody

Application
Recommended Usage

Immunohistochemistry

1:10-1:500

Immunohistochemistry-Paraffin

4-8 ug/ml

Western Blot

1.0 ug/ml

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, 2% Sucrose

Preservative

0.09% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: ADAMTS4

ADAMTS4 is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. ADAMTS4 lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma.

Long Name

A Disintegrin-like and Metalloproteinase Domain with Thrombospondin Motifs 4

Alternate Names

ADMP-1, Aggrecanase 1

Entrez Gene IDs

9507 (Human)

Gene Symbol

ADAMTS4

UniProt

O75173

Additional ADAMTS4 Products

Product Documents for ADAMTS4 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for ADAMTS4 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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