ADAMTS5 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-14533

Novus Biologicals, part of Bio-Techne
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NBP3-14533
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Bovine (100%), Hamster (95%), Monkey (100%), Mouse (100%), Porcine (100%), Primate (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit

Concentration

1 mg/ml

View all ADAMTS5 Antibodies »

Product Specifications

Immunogen

Synthetic 20 amino acid peptide from internal region of human ADAMTS5.

Epitope

Internal

Reactivity Notes

Expected reactivity based on percent sequence identity: Lizard (85%)

Specificity

Human ADAMTS5. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Clonality

Polyclonal

Host

Rabbit

Description

Product can be stored undiluted at 4C for up to 1 month.

Scientific Data Images for ADAMTS5 Antibody

Immunohistochemistry-Paraffin: ADAMTS5 Antibody [NBP3-14533]

Immunohistochemistry-Paraffin: ADAMTS5 Antibody [NBP3-14533]

Immunohistochemistry-Paraffin: ADAMTS5 Antibody [NBP3-14533] - Immunohistochemistry of formalin-fixed, paraffin-embedded human placenta after heat-induced antigen retrieval.

Applications for ADAMTS5 Antibody

Application
Recommended Usage

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.
Application Notes
.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS

Preservative

0.1% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

Background: ADAMTS5

ADAMTS5, also known as aggrecanase-2, is a Metallopeptidase M12B type protease that is responsible for degradation of the articular cartilage protein aggrecan. The protein contains a signal sequence, a prodomain with both a potential cysteine switch and a furin cleavage site, a metalloproteinase domain with a conserved zinc-binding motif and a 'met turn,' a disintegrin-like domain, and a spacer region between a thrombospondin type 1 motif and thrombospondin submotif. At least four transcript variants have been reported. ADAMTS5 has been implicated in inflammatory joint diseases. ADAMTS5 expression has been documented in a range of normal human tissues. ESTs have been isolated from human tissue libraries, including normal breast, embryo and heart and cancerous placenta and uterus.

Long Name

A Disintegrin-like and Metalloproteinase Domain with Thrombospondin Motifs 5

Alternate Names

ADAMTS11, ADMP-2, Aggrecanase 2

Gene Symbol

ADAMTS5

Additional ADAMTS5 Products

Product Documents for ADAMTS5 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for ADAMTS5 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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