Adenylate Cyclase 1 Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-92583

Novus Biologicals, part of Bio-Techne
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NBP2-92583-0.02ml
NBP2-92583-0.1ml
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Key Product Details

Species Reactivity

Validated:

Human, Mouse

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Adenylate Cyclase 1 Antibodies »

Product Summary for Adenylate Cyclase 1 Antibody - BSA Free

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 470-610 of human ADCY1 (NP_066939.1). NIETFFIVPSHRRKIFPGLILSDIKPAKRMKFKTVCYLLVQLMHCRKMFKAEIPFSNVMTCEDDDKRRALRTASEKLRNRSSFSTNVVYTTPGTRVNRYISRLLEARQTELEMADLNFFTLKYKHVEREQKYHQLQDEYFT

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

123 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Adenylate Cyclase 1 Antibody - BSA Free

Western Blot: Adenylate Cyclase 1 AntibodyBSA Free [NBP2-92583]

Western Blot: Adenylate Cyclase 1 AntibodyBSA Free [NBP2-92583]

Western Blot: Adenylate Cyclase 1 Antibody [NBP2-92583] - Analysis of extracts of various cell lines, using Adenylate Cyclase 1 .Exposure time: 90s.

Applications for Adenylate Cyclase 1 Antibody - BSA Free

Application
Recommended Usage

Western Blot

1:200-1:1000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS with 50% glycerol, pH7.3.

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Adenylate Cyclase 1

Adenylyl cyclases function to convert ATP to cyclic AMP in response to activation by a variety of hormones, neurotransmitters and other regulatory molecules. Cyclic AMP, in turn, activates several other target molecules to control a broad range of diverse phenomena such as metabolism, gene transcription and memory. Adenylyl cyclases respond to receptor-initiated signals, mediated by the Gs and Gi heterotrimeric G proteins. The binding of an agonist to a Gs-coupled receptor catalyzes the exchange of GDP (bound to Galpha s) for GTP, the dissociation of GTP-Galpha s from Gbetagamma and Galpha s)-mediated activation of adenylyl cyclase. Adenylyl cyclases type I (AC I) and III (AC III) have distinct staining within the cell nucleus of rat brain sensory neurons. AC I is expressed in myenteric ganglia as two bands of 160 kDa and 185 kDa by SDS-PAGE. Ca2+ stimulation of AC I and AC III is mediated by calmodulin. Protein associated with Myc (PAM) is a very potent inhibitor of AC I. A decrease in endogenous PAM levels in HeLa cells modulate both basal and agonist stimulated cAMP accumulation.

Long Name

Adenylate cyclase type 1

Alternate Names

ADCY1, Adenylyl cyclase 1, DFNB44, EC 4.6.1.1

Gene Symbol

ADCY1

Additional Adenylate Cyclase 1 Products

Product Documents for Adenylate Cyclase 1 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Adenylate Cyclase 1 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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