Adenylate Cyclase 1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-12505

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Validated:

Mouse, Rat, Rabbit

Applications

ELISA, Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Adenylate Cyclase 1 Antibodies »

Product Summary for Adenylate Cyclase 1 Antibody

Immunogen

Synthetic peptide taken within amino acid region 1030-1060 on rat/mouse Adenylyl Cyclase 1 protein.

Clonality

Polyclonal

Host

Rabbit

Scientific Data Images for Adenylate Cyclase 1 Antibody

Western Blot: Adenylate Cyclase 1 Antibody [NBP3-12505]

Western Blot: Adenylate Cyclase 1 Antibody [NBP3-12505]

Western Blot: Adenylate Cyclase 1 Antibody [NBP3-12505] - 1:500 antibody dilution in DiluObuffer.

Applications for Adenylate Cyclase 1 Antibody

Application
Recommended Usage

ELISA

1:10000

Immunoprecipitation

1:200

Western Blot

1:500
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

Contains Tris, HCl/glycine buffer (pH 7.4-7.8), 30% glycerol, 0.5% BSA, along with cryo-protective agents, and HEPES (exact storage and stabilization buffer information is proprietary).

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Store at -20C long term. Avoid freeze-thaw cycles.

Background: Adenylate Cyclase 1

Adenylyl cyclases function to convert ATP to cyclic AMP in response to activation by a variety of hormones, neurotransmitters and other regulatory molecules. Cyclic AMP, in turn, activates several other target molecules to control a broad range of diverse phenomena such as metabolism, gene transcription and memory. Adenylyl cyclases respond to receptor-initiated signals, mediated by the Gs and Gi heterotrimeric G proteins. The binding of an agonist to a Gs-coupled receptor catalyzes the exchange of GDP (bound to Galpha s) for GTP, the dissociation of GTP-Galpha s from Gbetagamma and Galpha s)-mediated activation of adenylyl cyclase. Adenylyl cyclases type I (AC I) and III (AC III) have distinct staining within the cell nucleus of rat brain sensory neurons. AC I is expressed in myenteric ganglia as two bands of 160 kDa and 185 kDa by SDS-PAGE. Ca2+ stimulation of AC I and AC III is mediated by calmodulin. Protein associated with Myc (PAM) is a very potent inhibitor of AC I. A decrease in endogenous PAM levels in HeLa cells modulate both basal and agonist stimulated cAMP accumulation.

Long Name

Adenylate cyclase type 1

Alternate Names

ADCY1, Adenylyl cyclase 1, DFNB44, EC 4.6.1.1

Gene Symbol

ADCY1

Additional Adenylate Cyclase 1 Products

Product Documents for Adenylate Cyclase 1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for Adenylate Cyclase 1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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