Key Product Details

Species Reactivity

Human

Applications

Immunoprecipitation, Western Blot (Negative)

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1.0 mg/ml

View all AKAP13 Antibodies »

Product Specifications

Immunogen

The immunogen recognized by this antibody maps to a region between residue 1850 and 1900 of human A kinase (PRKA) anchor protein 13 using the numbering given in entry NP_009131.2 (GeneID 11214).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for AKAP13 Antibody - BSA Free

Immunoprecipitation: AKAP13 Antibody [NB100-68213]

Immunoprecipitation: AKAP13 Antibody [NB100-68213]

Immunoprecipitation: AKAP13 Antibody [NB100-68213] - Detection of Human AKAP13/AKAP-Lbc on HeLa whole cell lysate using NB100-68213. AKAP13/AKAP-Lbc was also immunoprecipitated by rabbit anti-AKAP13/AKAP-Lbc antibody NB100-68214.

Applications for AKAP13 Antibody - BSA Free

Application
Recommended Usage

Immunoprecipitation

2-5 ug/mg lysate

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris-Citrate/Phosphate (pH 7.0 - 8.0)

Format

BSA Free

Preservative

0.09% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C. Do not freeze.

Background: AKAP13

The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. Alternative splicing of this gene results in at least 3 transcript variants encoding different isoforms containing a dbl oncogene homology (DH) domain and a pleckstrin homology (PH) domain. The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP binding proteins, resulting in the conversion of the inactive GTPase to the active form capable of transducing signals. The PH domain has multiple functions. Therefore, these isoforms function as scaffolding proteins to coordinate a Rho signaling pathway and, in addition, function as protein kinase A-anchoring proteins.

Alternate Names

A kinase (PRKA) anchor protein 13, AKAP-LbcAKAP-13, A-kinase anchor protein 13, A-kinase anchoring protein, ARHGEF13, Breast cancer nuclear receptor-binding auxiliary protein, BRXNon-oncogenic Rho GTPase-specific GTP exchange factor, c-lbc, FLJ11952, FLJ43341, Guanine nucleotide exchange factor Lbc, HA-3, HT31, Human thyroid-anchoring protein 31, LBCLBC oncogene, Lymphoid blast crisis oncogeneProtein kinase A-anchoring protein 13, p47, PROTO-LB, PROTO-LBC

Entrez Gene IDs

11214 (Human)

Gene Symbol

AKAP13

Additional AKAP13 Products

Product Documents for AKAP13 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for AKAP13 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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