AKR1B1 Antibody (CPTC-AKR1B1-3) [CoraFluor™ 1]

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-79930CL1

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Product Datasheet / COA / SDS

View Available Conjugates View Available Formulations

Conjugate

Catalog #

Unconjugated

NBP2-79796

Alexa Fluor 350

NBP2-79930AF350

Alexa Fluor 405

NBP2-79930AF405

Alexa Fluor 488

NBP2-79930AF488

Alexa Fluor 532

NBP2-79930AF532

Alexa Fluor 594

NBP2-79930AF594

Alexa Fluor 647

NBP2-79930AF647

Alexa Fluor 700

NBP2-79930AF700

Alexa Fluor 750

NBP2-79930AF750

Allophycocyanin

NBP2-79930APC

Biotin

NBP2-79930B

DyLight 350

NBP2-79930UV

DyLight 405

NBP2-79930V

DyLight 488

NBP2-79930G

DyLight 550

NBP2-79930R

DyLight 594

NBP2-79930DL594

DyLight 650

NBP2-79930C

DyLight 680

NBP2-79930FR

DyLight 755

NBP2-79930IR

FITC

NBP2-79930F

HRP

NBP2-79930H

Janelia Fluor 525

NBP2-79930JF525

Janelia Fluor 549

NBP2-79930JF549

Janelia Fluor 585

NBP2-79930JF585

Janelia Fluor 635

NBP2-79930JF635

Janelia Fluor 646

NBP2-79930JF646

Janelia Fluor 669

NBP2-79930JF669

PE

NBP2-79930PE

PerCP

NBP2-79930PCP

Forumulation

Catalog #

Azide and BSA Free

NBP2-79930

Product Summary
Applications
Preparation & Storage
Background
Product Documents
Specific Notices

Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Protein Array, Western Blot

Label

CoraFluor 1

Antibody Source

Monoclonal Mouse IgG₁ kappa Clone # CPTC-AKR1B1-3

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all AKR1B1 Antibodies »

Product Summary for AKR1B1 Antibody (CPTC-AKR1B1-3) [CoraFluor™ 1]

Immunogen

Recombinant human full-length AKR1B1 protein (Uniprot: P15121)

Localization

Cytoplasmic

Marker

Adrenal Marker

Clonality

Monoclonal

Host

Mouse

Isotype

IgG₁ kappa

Description

CoraFluor(TM) 1 is a high performance terbium-based TR-FRET (Time-Resolved Fluorescence Resonance Energy Transfer) or TRF (Time-Resolved Fluorescence) donor for high throughput assay development. CoraFluor(IM) 1 absorbs UV light at approximately 340 nm, and emits at approximately 490 nm, 545 nm, 585 nm and 620 nm. It is compatible with common acceptor dyes that absorb at the emission wavelengths of CoraFluor(TM) 1. CoraFluor(TM) 1 can be used for the development of robust and scalable TR-FRET binding assays such as target engagement, ternary complex, protein-protein interaction and protein quantification assays.

Applications for AKR1B1 Antibody (CPTC-AKR1B1-3) [CoraFluor™ 1]

Application

Recommended Usage

Immunocytochemistry/ Immunofluorescence

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.

Protein Array

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.

Application Notes

Optimal dilution of this antibody should be experimentally determined.

Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

PBS

Preservative

No Preservative

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C in the dark. Do not freeze.

Background: AKR1B1

Aldose reductase (also designated AKR1B1, ALDR1, ALR2 or AR) is member of the monomeric NADPH-dependent aldoketoreductase family. Aldose reductase, which has a molecular mass of 36 kDa, catalyzes the reduction of various aldehydes and has been implicated in the development of diabetic complications by catalyzing the reduction of the aldehyde form of glucose, to the corresponding sugar alcohol, sorbitol. This pathway plays a minor role in glucose metabolism in most tissues, however in diabetic hyperglycemia, cells undergoing insulin-independent uptake of glucose accumulate significant quantities of sorbitol. The resulting hyperosmotic stress to cells may be a cause of diabetic complications such as neuropathy, retinopathy, and cataracts. Aldose reductase is very similar to human aldehyde reductase, bovine prostaglandin F synthase and to the European common frog protein, rho-crystallin.

Alternate Names

ADR, Aldehyde reductase, Aldo-keto reductase family 1 member B1, aldo-keto reductase family 1, member B1 (aldose reductase), ALDR1aldose reductase, ALR2, ARaldehyde reductase 1, EC 1.1.1, EC 1.1.1.21, Lii5-2 CTCL tumor antigen, low Km aldose reductase, MGC1804

Gene Symbol

AKR1B1

Additional AKR1B1 Products

Product Documents for AKR1B1 Antibody (CPTC-AKR1B1-3) [CoraFluor™ 1]

Product Datasheets

Download Product Datasheets

COA

SDS

Product Specific Notices for AKR1B1 Antibody (CPTC-AKR1B1-3) [CoraFluor™ 1]

CoraFluor (TM) is a trademark of Bio-Techne Corp. Sold for research purposes only under agreement from Massachusetts General Hospital. US patent 2022/0025254

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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