alpha 2-Macroglobulin-like 1/A2ML1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-84392

Novus Biologicals, part of Bio-Techne
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NBP1-84392
NBP1-84392-25ul
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Key Product Details

Validated by

Orthogonal Validation, Independent Antibodies

Species Reactivity

Validated:

Human

Cited:

Mouse

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin

Cited:

IF/IHC

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all alpha 2-Macroglobulin-like 1/A2ML1 Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: RYTYGKPMLGAVQVSVCQKANTYWYREVEREQLPDKCRNLSGQTDKTGCFSAPVDMATFDLIGYAYSHQINIVATVVEEGTGVEANATQNIY

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

161 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for alpha 2-Macroglobulin-like 1/A2ML1 Antibody

Immunohistochemistry-Paraffin: alpha 2-Macroglobulin-like 1/A2ML1 Antibody [NBP1-84392]

Immunohistochemistry-Paraffin: alpha 2-Macroglobulin-like 1/A2ML1 Antibody [NBP1-84392]

Immunohistochemistry-Paraffin: alpha 2-Macroglobulin-like 1/A2ML1 Antibody [NBP1-84392] - Analysis in human esophagus and liver tissues. Corresponding A2ML1 RNA-seq data are presented for the same tissues.
Immunohistochemistry-Paraffin: alpha 2-Macroglobulin-like 1/A2ML1 Antibody [NBP1-84392]

Immunohistochemistry-Paraffin: alpha 2-Macroglobulin-like 1/A2ML1 Antibody [NBP1-84392]

Immunohistochemistry-Paraffin: alpha 2-Macroglobulin-like 1/A2ML1 Antibody [NBP1-84392] - Staining of human esophagus, liver, skin and tonsil using Anti-A2ML1 antibody NBP1-84392 (A) shows similar protein distribution across tissues to independent antibody NBP2-32647 (B).
Immunohistochemistry-Paraffin: alpha 2-Macroglobulin-like 1/A2ML1 Antibody [NBP1-84392]

Immunohistochemistry-Paraffin: alpha 2-Macroglobulin-like 1/A2ML1 Antibody [NBP1-84392]

Immunohistochemistry-Paraffin: alpha 2-Macroglobulin-like 1/A2ML1 Antibody [NBP1-84392] - Staining of human skin shows strong cytoplasmic positivity in epidermal cells.
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Applications for alpha 2-Macroglobulin-like 1/A2ML1 Antibody

Application
Recommended Usage

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: alpha 2-Macroglobulin-like 1/A2ML1

The alpha-macroglobulin (AM) superfamily of proteins contains both complement components and protease inhibitors, including A2M (MIM 103950) and A2ML1. AM proteins display a unique trap mechanism of inhibition, by which the AM inhibitor undergoes a major conformational change upon its cleavage by a protease, thus trapping the protease and blocking it from subsequent substrate binding (Galliano et al., 2006 [PubMed 16298998]).[supplied by OMIM]

Alternate Names

A2ML1, alpha 2Macroglobulin like 1, CPAMD9

Entrez Gene IDs

144568 (Human)

Gene Symbol

A2ML1

UniProt

A8K2U0 (Human)

Additional alpha 2-Macroglobulin-like 1/A2ML1 Products

Product Documents for alpha 2-Macroglobulin-like 1/A2ML1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for alpha 2-Macroglobulin-like 1/A2ML1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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