alpha-2A Adrenergic R/ADRA2A Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-10657

Novus Biologicals, part of Bio-Techne
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NBP3-10657-100ul
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit

Concentration

0.5 mg/ml

View all alpha-2A Adrenergic R/ADRA2A Antibodies »

Product Summary for alpha-2A Adrenergic R/ADRA2A Antibody

Immunogen

The immunogen is a synthetic peptide directed towards the C-terminal region of Human alpha-2A Adrenergic R/ADRA2A (NP_000672). Peptide sequence RRPERGPRGKGKARASQVKPGDSLPRRGPGATGIGTPAAGPGEERVGAAK

Clonality

Polyclonal

Host

Rabbit

Theoretical MW

49 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for alpha-2A Adrenergic R/ADRA2A Antibody

Western Blot: alpha-2A Adrenergic R/ADRA2A Antibody [NBP3-10657]

Western Blot: alpha-2A Adrenergic R/ADRA2A Antibody [NBP3-10657]

Western Blot: alpha-2A Adrenergic R/ADRA2A Antibody [NBP3-10657] - Western blot analysis of alpha-2A Adrenergic R/ADRA2A in Fetal Thymus as a positive control. Antibody dilution at 1.0 ug/ml

Applications for alpha-2A Adrenergic R/ADRA2A Antibody

Application
Recommended Usage

Western Blot

1.0 ug/ml
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, 2% Sucrose

Preservative

0.09% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: alpha-2A Adrenergic R/ADRA2A

This study investigates the involvement of alpha2-adrenergic receptors (AR) in mouse brain induced by a low dose of methamphetamine (METH, 2 mg/kg). Immunohistochemical studies show that alpha2A-AR increased in the dentate gyrus area of the hippocampus 24 h after five repeated administrations of METH. The hippocampal alpha2A-AR proteins rose 3.2-fold when compared to the saline-administered mice. The other adrenergic receptor, alpha1D-AR, were not changed by the treatment. Moreover, alphao-subunits of GTP-binding proteins (Galphao), one of the downstream molecules of alpha2A-AR, was also increased by the treatment. These suggest that the repeated administration of low-doses of METH causes quantitative changes of the signaling of alpha2A-AR in the mouse hippocampus.

Long Name

Alpha-2A Adrenergic Receptor

Alternate Names

a-2A AdrenergicR, ADRA2A, alpha2A AdrenergicR, ZNF32

Gene Symbol

ADRA2A

Additional alpha-2A Adrenergic R/ADRA2A Products

Product Documents for alpha-2A Adrenergic R/ADRA2A Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for alpha-2A Adrenergic R/ADRA2A Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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