alpha-2B Adrenergic R/ADRA2B Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-49470

Novus Biologicals, part of Bio-Techne
Catalog #
Availability
Size / Price
Qty
NBP2-49470
NBP2-49470-25ul
Print Quote
Bulk Order
100% Guarantee

Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all alpha-2B Adrenergic R/ADRA2B Antibodies »

Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: IAKRSNRRGPRAKGGPGQGESKQPRPDHGGALASAKLPALASVASAREVN

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for alpha-2B Adrenergic R/ADRA2B Antibody

Immunohistochemistry-Paraffin: alpha-2B Adrenergic R/ADRA2B Antibody [NBP2-49470]

Immunohistochemistry-Paraffin: alpha-2B Adrenergic R/ADRA2B Antibody [NBP2-49470]

Immunohistochemistry-Paraffin: alpha-2B Adrenergic R/ADRA2B Antibody [NBP2-49470] - Staining of human cerebellum shows strong cytoplasmic positivity in Purkinje cells.

Applications for alpha-2B Adrenergic R/ADRA2B Antibody

Application
Recommended Usage

Immunohistochemistry

1:200 - 1:500

Immunohistochemistry-Paraffin

1:200 - 1:500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: alpha-2B Adrenergic R/ADRA2B

Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. This gene encodes the alpha2B subtype, which was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization; this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. This gene contains no introns in either its coding or untranslated sequences. (provided by RefSeq)

Long Name

Alpha-2B Adrenergic Receptor

Alternate Names

a-2B AdrenergicR, ADRA2B, ADRA2L1, ADRA2RL1, ADRARL1, alpha2B AdrenergicR

Gene Symbol

ADRA2B

Additional alpha-2B Adrenergic R/ADRA2B Products

Product Documents for alpha-2B Adrenergic R/ADRA2B Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for alpha-2B Adrenergic R/ADRA2B Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Privacy and Cookie Policy
Site Map
© Copyright 2024 Bio-Techne. All Rights Reserved.