alpha Adducin Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-99388

Novus Biologicals, part of Bio-Techne
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NBP2-99388-100ul
NBP2-99388-50ul
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all alpha Adducin Antibodies »

Product Summary for alpha Adducin Antibody

Immunogen

Produced in rabbits immunized with a synthetic peptide corresponding to the center region of the Human alpha Adducin.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

This antibody can be stored at 2C to 8C for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20C to -80C. Avoid repeated freeze-thaw cycles.

Scientific Data Images for alpha Adducin Antibody

Immunohistochemistry-Paraffin: alpha Adducin Antibody [NBP2-99388]

Immunohistochemistry-Paraffin: alpha Adducin Antibody [NBP2-99388]

Immunohistochemistry-Paraffin: alpha Adducin Antibody [NBP2-99388] - Immunochemical staining of human alpha Adducin in human lung cancer with rabbit polyclonal antibody at 1:300 dilution, formalin-fixed paraffin embedded sections.
Immunohistochemistry-Paraffin: alpha Adducin Antibody [NBP2-99388]

Immunohistochemistry-Paraffin: alpha Adducin Antibody [NBP2-99388]

Immunohistochemistry-Paraffin: alpha Adducin Antibody [NBP2-99388] - Immunochemical staining of human alpha Adducin in human kidney with rabbit polyclonal antibody at 1:300 dilution, formalin-fixed paraffin embedded sections.

Applications for alpha Adducin Antibody

Application
Recommended Usage

Immunohistochemistry-Paraffin

1:200-1:1000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Antigen and protein A Affinity-purified

Formulation

PBS

Preservative

0.03% Proclin 300

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: alpha Adducin

Adducin is a membrane skeletal protein that binds to actin filaments (F-actin) and promotes the association of spectrin with F-actin to form a spectrin-actin meshwork beneath plasma membranes (1-2). Adducin is a heterodimeric protein that consists of related subunits; alpha and beta, or alpha and gamma subunits (3). Adducin binds with high affinity to Ca(2+)/calmodulin and is a substrate for protein kinase C (PKC), and protein kinase A (PKA) (4). PKA specifically phosphorylates Ser408, Ser436, and Ser481 located in the neck domain of alpha Adducin. Phosphorylation of Adducin alpha by Rho-kinase at Thr445 and Thr480 enhances the F-actin-binding activity of Adducin alpha (5).

Alternate Names

ADDA, adducin 1 (alpha), alpha-adducin, erythrocyte adducin alpha subunit, Erythrocyte adducin subunit alpha, MGC3339, MGC44427

Gene Symbol

ADD1

Additional alpha Adducin Products

Product Documents for alpha Adducin Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for alpha Adducin Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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