alpha Endosulfine Antibody (1H7)

Novus Biologicals, part of Bio-Techne | Catalog # H00002029-M02

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human

Applications

ELISA, Sandwich ELISA, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2b Kappa Clone # 1H7

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all alpha Endosulfine Antibodies »

Product Specifications

Immunogen

ENSA (AAH00436, 1 a.a. ~ 121 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. MSQKQEEENPAEETGEEKQDTQEKEGILPERAEEAKLKAKYPSLGQKPGGSDFLMKRLQKGQKYFDSGDYNMAKAKMKNKQLPSAGPDKNLVTGDHIPTPQDLPQRKSSLVTSKLAGGQVE

Localization

Cytoplasmic

Specificity

ENSA - endosulfine alpha

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2b Kappa

Description

Quality control test: Antibody Reactive Against Recombinant Protein.

Scientific Data Images for alpha Endosulfine Antibody (1H7)

Western Blot: alpha Endosulfine Antibody (1H7) [H00002029-M02]

Western Blot: alpha Endosulfine Antibody (1H7) [H00002029-M02]

Western Blot: alpha Endosulfine Antibody (1H7) [H00002029-M02] - ENSA monoclonal antibody (M02), clone 1H7 Analysis of ENSA expression in K-562.
Sandwich ELISA: alpha Endosulfine Antibody (1H7) [H00002029-M02] - Detection limit for recombinant GST tagged ENSA is approximately 0.1ng/ml as a capture antibody.

Applications for alpha Endosulfine Antibody (1H7)

Application
Recommended Usage

Western Blot

1:500
Application Notes
Antibody reactivity against cell lysate and recombinant protein for WB. It has also been used for ELISA.

Formulation, Preparation, and Storage

Purification

IgG purified

Formulation

In 1x PBS, pH 7.4

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: alpha Endosulfine

The protein encoded by this gene belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. ABCC8 is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed.

Alternate Names

alpha-endosulfine, ARPP-19eMGC4319, endosulfine alpha, MGC78563, MGC8394

Entrez Gene IDs

2029 (Human)

Gene Symbol

ENSA

OMIM

603061 (Human)

UniProt

AAH00436 (Human)

Additional alpha Endosulfine Products

Product Documents for alpha Endosulfine Antibody (1H7)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for alpha Endosulfine Antibody (1H7)

This product is produced by and distributed for Abnova, a company based in Taiwan.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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