alpha Endosulfine Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-13963

Novus Biologicals, part of Bio-Techne
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NBP2-13963
NBP2-13963-25ul
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Key Product Details

Species Reactivity

Validated:

Human, Zebrafish

Cited:

Fish - Danio rerio (Zebrafish)

Predicted:

Mouse (97%), Rat (97%). Backed by our 100% Guarantee.

Applications

Validated:

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Cited:

IF/IHC

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all alpha Endosulfine Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: MSQKQEEENPAEETGEEKQDTQEKEGILPERAEEAK

Reactivity Notes

Use in Zebrafish reported in secitific publication PMID: 32454406

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for alpha Endosulfine Antibody

Western Blot: alpha Endosulfine Antibody [NBP2-13963]

Western Blot: alpha Endosulfine Antibody [NBP2-13963]

Western Blot: alpha Endosulfine Antibody [NBP2-13963] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10
Lane 2: Human cell line RT-4
Lane 3: Human cell line U-251MG sp
Immunocytochemistry/ Immunofluorescence: alpha Endosulfine Antibody [NBP2-13963]

Immunocytochemistry/ Immunofluorescence: alpha Endosulfine Antibody [NBP2-13963]

Immunocytochemistry/Immunofluorescence: alpha Endosulfine Antibody [NBP2-13963] - Immunofluorescent staining of human cell line PC-3 shows localization to nucleus & nucleoli.
Immunohistochemistry-Paraffin: alpha Endosulfine Antibody [NBP2-13963]

Immunohistochemistry-Paraffin: alpha Endosulfine Antibody [NBP2-13963]

Immunohistochemistry-Paraffin: alpha Endosulfine Antibody [NBP2-13963] - Staining of human esophagus shows moderate cytoplasmic and nuclear positivity in squamous epithelial cells.

Applications for alpha Endosulfine Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:200 - 1:500

Immunohistochemistry-Paraffin

1:200 - 1:500

Western Blot

0.04-0.4 ug/ml

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: alpha Endosulfine

alpha Endosulfine is encoded by this gene belongs to a highly conserved cAMP-regulated phosphoprotein (ARPP) family. This protein was identified as an endogenous ligand for the sulfonylurea receptor, ABCC8/SUR1. alpha Endosulfine is the regulatory subunit of the ATP-sensitive potassium (KATP) channel, which is located on the plasma membrane of pancreatic beta cells and plays a key role in the control of insulin release from pancreatic beta cells. This protein is thought to be an endogenous regulator of KATP channels. In vitro studies have demonstrated that this protein modulates insulin secretion through the interaction with KATP channel, and this gene has been proposed as a candidate gene for type 2 diabetes. At least eight alternatively spliced transcript variants encoding distinct isoforms have been observed.

Alternate Names

alpha-endosulfine, ARPP-19eMGC4319, endosulfine alpha, MGC78563, MGC8394

Gene Symbol

ENSA

Additional alpha Endosulfine Products

Product Documents for alpha Endosulfine Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for alpha Endosulfine Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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